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https://hdl.handle.net/2440/17122
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Type: | Journal article |
Title: | Nipple-areolar pigmentation: histology and potential for reconstitution in breast reconstruction |
Author: | Dean, N. Haynes, J. Brennan, J. Neild, T. Goddard, C. Dearman, B. Cooter, R. |
Citation: | Journal of Plastic, Reconstructive and Aesthetic Surgery, 2005; 58(2):202-208 |
Publisher: | Print Edition - Churchill Livingstone |
Issue Date: | 2005 |
ISSN: | 1748-6815 1465-3087 |
Statement of Responsibility: | Nicola Dean, Julie Haynes, Jim Brennan, Tim Neild, Chris Goddard, Bronwyn Dearman and Rod Cooter |
Abstract: | The makeup of nipple-areolar skin, in terms of its melanin and melanocyte content has not previously been established. This histological information is required if pigmentation of the reconstructed nipple-areola is to be successful in post-mastectomy breast reconstruction. We describe examination of 200 parallel sections of nipple-areolar skin of 20 women using histochemical (Masson-Fontana) and immunohistochemical (Mel-5) techniques, evaluated using quantitative image analysis. The amount of melanin present per length of basement membrane was 2.14 times higher in areolar skin than breast skin. The ratio of melanocytes to keratinocytes was 1:9.7 in areolar skin vs. 1:14.7 in breast skin. We also describe a cell culture and skin construct method using autologous human serum without toxic growth promoting additives, which could be used in the clinical setting of nipple-areolar reconstruction. |
Keywords: | Nipples Cells, Cultured Keratinocytes Melanocytes Humans Melanins Skin Pigmentation Mammaplasty Immunohistochemistry Analysis of Variance Female |
Description: | Copyright © 2004 The British Association of Plastic Surgeons Published by Elsevier Ltd. |
Provenance: | Former title: British Journal of Plastic Surgery |
DOI: | 10.1016/j.bjps.2004.10.027 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/707671/description#description |
Published version: | http://dx.doi.org/10.1016/j.bjps.2004.10.027 |
Appears in Collections: | Anatomical Sciences publications Aurora harvest 2 |
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