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https://hdl.handle.net/2440/17128
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dc.contributor.author | Yang, L. | - |
dc.contributor.author | Jones, N. | - |
dc.contributor.author | Blumbergs, P. | - |
dc.contributor.author | Van Den Heuvel, C. | - |
dc.contributor.author | Bradford, E. | - |
dc.contributor.author | Manavis, J. | - |
dc.contributor.author | Sarvestani, G. | - |
dc.contributor.author | Ghabriel, M. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Clinical Neuroscience, 2005; 12(3):276-284 | - |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.issn | 1532-2653 | - |
dc.identifier.uri | http://hdl.handle.net/2440/17128 | - |
dc.description | Copyright © 2005 Elsevier Ltd All rights reserved. | - |
dc.description.abstract | The post-traumatic inflammatory response in acute spinal cord contusion injury was studied in the rat. Mild and severe spinal cord injury (SCI) was produced by dropping a 10 g weight from 3 and 12 cm at the T12 vertebral level. Increased immunoreactivity of TNF-alpha in mild and severe SCI was detected in neurons at 1 h post-injury, and in neurons and microglia at 6 h post-injury, with a less significant increase in mild SCI. Expression was short-lived and declined sharply by 1 d post-injury. RT-PCR showed an early significant up-regulation of IL-1 beta, IL-6 and TNF-alpha mRNAs, maximal at 6 h post-injury with return to control levels by 24 h post-injury, the changes being less statistically significantly in mild SCI. Western blot showed early transient increases of IL-1 beta, IL-6 and TNF-alpha proteins in severe SCI but not mild SCI. Immunocytochemical, western blotting and RT-PCR analyses suggest that endogenous cells (neurons and microglia) in the spinal cord, not blood-borne leucocytes, contribute to IL-1 beta, IL-6 and TNF-alpha production in the post-traumatic inflammatory response and that their up-regulation is greater in severe than mild SCI. | - |
dc.description.statementofresponsibility | Liqun Yang, Nigel R. Jones, Peter C. Blumbergs, Corinna Van Den Heuvel, Emma J. Moore, Jim Manavis, Ghafar T. Sarvestani and Mounir N. Ghabriel | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/623056/description#description | - |
dc.language.iso | en | - |
dc.publisher | Churchill Livingstone | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jocn.2004.06.011 | - |
dc.subject | interleukin-1β | - |
dc.subject | interleukin-6 | - |
dc.subject | tumour necrosis factor-* | - |
dc.subject | traumatic spinal cord injury | - |
dc.subject | microglia | - |
dc.subject | inflammatory response | - |
dc.title | Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the rat | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jocn.2004.06.011 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Van Den Heuvel, C. [0000-0003-0664-8935] | - |
dc.identifier.orcid | Ghabriel, M. [0000-0002-9153-271X] | - |
Appears in Collections: | Anatomical Sciences publications Aurora harvest 6 |
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