Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17135
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLindsay, D.en
dc.contributor.authorBarker, P.en
dc.contributor.authorNorthrop, A.en
dc.contributor.authorSetchell, B.en
dc.contributor.authorFaichney, G.en
dc.date.issued2005en
dc.identifier.citationJournal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology, 2005; 175(6):413-422en
dc.identifier.issn0174-1578en
dc.identifier.issn1432-136Xen
dc.identifier.urihttp://hdl.handle.net/2440/17135-
dc.description.abstractPregnant ewes with catheters implanted in an artery and the uterine and recurrent tarsal veins were infused at a constant rate with U−¹⁴C-labelled glucose, alanine or bicarbonate. Measurements were made of the overall and local fractional contribution of glucose and alanine to CO₂ production and of the extent of interconversion of these metabolites. In the whole animal, by coupling the results with the authors’ previous study of lactate metabolism, a solution was obtained to an open unrestricted 4-compartment model of the exchange of carbon between glucose, lactate, alanine and CO₂. A more limited study was made with non-pregnant sheep because complete data for lactate interactions with alanine were not available. Our analysis of glucose/lactate/alanine/CO₂ interactions in pregnant sheep suggests that about two-thirds of the glycogenic carbon was oxidised fairly directly to CO₂. There was relatively little recycling of glucose carbon through lactate and alanine so that most of the remaining glycogenic carbon was stored as product with relatively long turnover time. It is possible that much of this was in the form of muscle glycogen, and analysis of glycogenic carbon exchange across the hind limb muscle was consistent with this conclusion. In non-pregnant ewes, the findings, although incomplete, suggested that there were no great differences from the findings in pregnant ewes.en
dc.description.statementofresponsibilityDerek B. Lindsay, Patrick J. Barker, Andrew J. Northrop, Brian P. Setchell, Graham J. Faichneyen
dc.language.isoenen
dc.publisherSpringeren
dc.subjectPregnant uterus; Muscle; Glucose; Alanine; Lactate; Irreversible loss; Fractional extraction; Oxidation; Compartmental analysisen
dc.titleThe recycling of carbon in glucose, lactate and alanine in sheepen
dc.typeJournal articleen
dc.identifier.rmid0020051048en
dc.identifier.doi10.1007/s00360-005-0003-5en
dc.identifier.pubid54619-
pubs.library.collectionAnatomical Sciences publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Anatomical Sciences publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.