Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17150
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dc.contributor.authorBriggs, A.en
dc.contributor.authorWark, J.en
dc.contributor.authorKantor, S.en
dc.contributor.authorTeh, R.en
dc.contributor.authorGreig, A.en
dc.contributor.authorFazzalari, N.en
dc.contributor.authorBennell, K.en
dc.date.issued2005en
dc.identifier.citationJournal of Clinical Densitometry, 2005; 8(3):314-319en
dc.identifier.issn1094-6950en
dc.identifier.issn1559-0747en
dc.identifier.urihttp://hdl.handle.net/2440/17150-
dc.description.abstractAnalysis of apparent bone mineral density (BMD) in the lumbar spine is commonly based on anteroposterior (AP) scanning using dual-energy X-ray absorptiometry (DXA). Although not widely used, clinically important information can also be derived from lateral scanning. Vertebral bone density, and therefore strength, can may vary in different subregions of the vertebral body. Therefore, subregional BMD measurements might be informative about fracture risk. However, the intrarater and interrater precision of in vivo subregional BMD assessments from lateral DXA remains unknown. Ten normal, young (mean: 24 yr) and 10 older (mean: 63 yr) individuals with low BMD were scanned on one occasion using an AP/lateral sequence. Each lateral scan was reanalyzed six times at L2 by three raters to determine the intrarater and interrater precision in selecting seven regions of interest (subregions). Precision was expressed using percentage coefficients of variation (% CV) and intraclass correlation coefficients (ICC). Intrarater precision ranged from ICC(1,1) 0.971 to 0.996 (% CV: 0.50-3.68) for the young cohort and ICC(1,1) 0.934 to 0.993 (% CV: 1.46-5.30) for the older cohort. Interrater precision ranged from ICC(2,1) 0.804 to 0.915 (% CV: 1.11-2.35) for the young cohort and ICC(2,1) 0.912 to 0.984 (% CV: 1.85-4.32) for the older cohort. Scanning a subgroup of participants twice with repositioning was used to assess short-term in vivo precision. At L2, short-term in vivo precision ranged from ICC(1,1) 0.867 to 0.962 (% CV: 3.38-9.61), at L3 from ICC(1,1) 0.961 to 0.988 (% CV: 2.02-5.57) and using an L2/L3 combination from ICC(1,1) 0.942 to 0.980 (% CV: 2.04-4.61). This study demonstrated moderate to high precision for subregional analysis of apparent BMD in the lumbar spine using lateral DXA in vivo.en
dc.description.statementofresponsibilityBriggs AM, Wark JD, Kantor S, Teh R, Greig AM, Fazzalari NL, Bennell KL.en
dc.language.isoenen
dc.publisherHumana Press Incen
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/16055962en
dc.subjectLumbar Vertebrae; Humans; Osteoporosis; Observer Variation; Absorptiometry, Photon; Sensitivity and Specificity; Reproducibility of Results; Bone Density; Supine Position; Adult; Aged; Female; Maleen
dc.titleIn vivo intrarater and interrater precision of measuring apparent bone mineral density in vertebral subregions using supine lateral dual-energy X-ray absorptiometryen
dc.typeJournal articleen
dc.identifier.rmid0020051069en
dc.identifier.doi10.1385/JCD:8:3:314en
dc.identifier.pubid54607-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pathology publications

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