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|Title:||Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats|
|Citation:||Brain Research, 2005; 1062(1-2):171-174|
|Publisher:||Elsevier Science Bv|
|Christine A. O'Connora, Ibolja Cernakc and Robert Vink|
|Abstract:||Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury.|
|Keywords:||neurotrauma; hormone; female; blood brain barrier; brain injury|
|Description:||Available online 26 October 2005.|
|Rights:||Copyright © 2005 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Pathology publications|
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