Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17161
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Type: Journal article
Title: Bioceramics composition modulate resorption of human osteoclasts
Author: Ramaswamy, Y.
Haynes, D.
Berger, G.
Gildenhaar, R.
Lucas, H.
Holding, C.
Zreiqat, H.
Citation: Journal of Materials Science-Materials in Medicine, 2005; 16(12):1199-1205
Publisher: Kluwer Academic Publ
Issue Date: 2005
ISSN: 0957-4530
1573-4838
Statement of
Responsibility: 
Y. Ramaswamy, D. R. Haynes, G. Berger, R. Gildenhaar, H. Lucas, C. Holding and H. Zreiqat
Abstract: Biomaterials used in bone regeneration are designed to be gradually resorbed by the osteoclast and replaced by new bone formed through osteoblastic activity. The aim of the present study is to analyze the role of osteoclasts in the resorption process. The attachment of human osteoclasts and the appearance of their resorption lacunae, when cultured on either the resorbable crystalline, calcium orthophosphate materials or on the long-term stable bioceramic material was investigated. The resorbable materials contain Ca10[K,Na](PO4)7 (AW-Si) and Ca2KNa(PO4)2 (GB14, GB9 & D9/25) as their main crystal phases, however they differ in their total solubility. These differences result from small variations in the composition. The long-term stable material consist of about 30% fluorapatite beside calcium zirconium phosphate (Ca5(PO4)3F + CaZr4(PO4)6) and shows a very small solubility. AW-Si has an alkali containing crystalline phase, Ca10[K,Na](PO4). While GB14, GB9 and D9/25 contain the crystalline phase Ca2KNa(PO4)2 with small additions of crystalline and amorphous diphosphates and/or magnesium potassium phosphate (GB14). D9/25 and AW-Si is less soluble compared to GB14, and GB9 among the resorbable materials. Resorbable and long-term stable materials vary in their chemical compositions, solubility, and surface morphology. Osteoclasts modified the surface in their attempts to resorb the materials irrespective of the differences in their physical and chemical properties. The depth and morphology of the resorption imprints were different depending on the type of material. These changes in the surface structure created by osteoclasts are likely to affect the way osteoblasts interact with the materials and how bone is subsequently formed.
Keywords: Osteoclasts; Humans; Bone Resorption; Biocompatible Materials; Ceramics; Microscopy, Electron, Scanning; Solubility
Rights: © Springer
RMID: 0020051431
DOI: 10.1007/s10856-005-4729-0
Appears in Collections:Pathology publications

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