Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17169
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Type: Journal article
Title: Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?
Author: Krisstiansson, P.
Holding, C.
Hughes, S.
Haynes, D.
Citation: Annals of the New York Academy of Sciences, 2005; 1041(1):317-319
Publisher: New York Acad Sciences
Issue Date: 2005
ISSN: 0077-8923
1749-6632
Abstract: This study was designed to test the hypothesis that relaxin stimulates bone resorption by regulating the production of several mediators that stimulate osteoclast formation. The levels of mediators were measured in response to differing relaxin concentrations in supernatants from peripheral blood mononuclear cells (PBMCs), MCF-7 breast cancer cells, and normal human osteoblasts. Although all cell types expressed mRNA for the relaxin receptor (LGR7), only PBMCs responded to relaxin at physiologic levels by increasing tumor necrosis factor- and interleukin-1ß secretion. The findings indicate that PBMCs should be studied in relation to the effect of relaxin on inflammation and bone destruction caused by osteoclasts.
Keywords: relaxin; bone resorption; PBMCs; mRNA
Description: Relaxin and Related Peptides: Fourth International Conference / O.D. Sherwood, P.A. Fields, B.G. Steinetz (eds.): pp.317-319
Rights: ©2005 New York Academy of Sciences, all rights reserved.
RMID: 0020052086
DOI: 10.1196/annals.1282.050
Appears in Collections:Pathology publications

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