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Type: Journal article
Title: Brain pharmacokinetics of lignocaine before and following intravenous perfluorocarbon emulsion infusion in sheep
Author: Doolette, D.
Upton, R.
Martinez, A.
Citation: Clinical and Experimental Pharmacology and Physiology, 2005; 32(5-6):367-371
Publisher: Blackwell Publishing Asia
Issue Date: 2005
ISSN: 0305-1870
Abstract: 1. Perfluorocarbon emulsions have potential medical applications, particularly as temporary oxygen carriers and are likely to be coadministered with other intravenous drugs. It is possible that perfluorocarbon emulsions may alter the disposition of other drugs in the body. 2. In the present study, we examined the brain pharmacokinetics of a 5 min infusion of 100 mg lignocaine in three chronically instrumented sheep before and after the administration of a new investigational perflurocarbon emulsion (Oxygent; Alliance Pharmaceutical, San Diego, CA, USA). 3. The rate constant for the blood : brain equilibration of lignocaine was larger after perflubron administration. This change could not be attributed to a change in brain blood flow and, therefore, may be the result of a change in the free fraction of lignocaine in the blood.
Keywords: Brain; Animals; Sheep; Lidocaine; Fluorocarbons; Infusions, Intravenous; Female
RMID: 0020050304
DOI: 10.1111/j.1440-1681.2005.04197.x
Appears in Collections:Anaesthesia and Intensive Care publications

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