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dc.contributor.authorDodd, J.en
dc.contributor.authorCrowther, C.en
dc.contributor.authorCincotta, R.en
dc.contributor.authorFlenady, V.en
dc.contributor.authorRobinson, J.en
dc.identifier.citationActa Obstetricia et Gynecologica Scandinavica, 2005; 84(6):526-533en
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstractAIM: The aim of this study is to assess the role of progesterone in preterm birth prevention. METHODS: A MEDLINE search (from 1966 to the present; date of last search January 2005) was performed - using the key words progesterone, pregnancy, preterm birth, preterm labor, and randomized, controlled trial - in order to identify randomized, controlled trials in which progesterone (either intramuscular or vaginal administration) was compared with placebo or no treatment. Data were extracted and a meta-analysis was performed. RESULTS: Seven randomized, controlled trials were identified. Women who received progesterone were statistically significantly less likely to give birth before 37 weeks (seven studies, 1020 women, RR = 0.58, 95% CI = 0.48-0.70), to have an infant with birth weight of < or =2.5 kg (six studies, 872 infants, RR = 0.62, 95% CI = 0.49-0.78), or to have an infant diagnosed with intraventricular hemorrhage (one study, 458 infants, RR = 0.25, 95% CI = 0.08-0.82). CONCLUSIONS: For progesterone supplementation to be advocated for women at the risk of preterm birth, the prolongation of gestation demonstrated in this meta-analysis must translate into improved infant outcomes, including a reduction in mortality. There is currently insufficient information to allow recommendations regarding the optimal dose, route, and timing of administration of progesterone supplementation.en
dc.description.statementofresponsibilityJodie M. Dodd, Caroline A. Crowther, Robert Cincotta, Vicki Flenady, Jeffrey S. Robinsonen
dc.publisherMunksgaard Int Publ Ltden
dc.subjectHumans; Birth Weight; Progesterone; Tocolytic Agents; Administration, Intravaginal; Gestational Age; Pregnancy; Infant, Newborn; Female; Obstetric Labor, Premature; Randomized Controlled Trials as Topicen
dc.titleProgesterone supplementation for preventing preterm birth: a systematic review and meta-analysisen
dc.typeJournal articleen
pubs.library.collectionObstetrics and Gynaecology publicationsen
dc.identifier.orcidDodd, J. [0000-0002-6363-4874]en
dc.identifier.orcidCrowther, C. [0000-0002-9079-4451]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
Appears in Collections:Obstetrics and Gynaecology publications

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