Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/22730
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Type: Journal article
Title: The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension
Author: Rasmussen, M.
Upton, R.
Grant, C.
Martinez, A.
Cold, G.
Ludbrook, G.
Citation: Anesthesia and Analgesia, 2006; 102(6):1823-1829
Publisher: Lippincott Williams & Wilkins
Issue Date: 2006
ISSN: 0003-2999
1526-7598
Statement of
Responsibility: 
Mads Rasmussen, Richard N. Upton, Cliff Grant, Allison M. Martinez, Georg E. Cold, and Guy Ludbrook
Abstract: The effect of indomethacin in reducing intracranial pressure (ICP) may be dependent on the choice of anesthetic regimen. We studied the effects of indomethacin on ICP and cerebral blood flow (CBF) during isoflurane or propofol anesthesia in a sheep model of intracranial hypertension. A crossover design was applied in which six sheep were anesthetized with isoflurane and propofol in a random order. Anesthetic depth was measured with response and state entropy. Changes in CBF, ICP, mean arterial blood pressure, arterio-venous oxygen difference, and Paco2 were measured at specific times before and after an IV indomethacin bolus (0.2 mg/kg). Response and state entropy values during anesthesia were similar in both groups. Isoflurane and propofol reduced CBF by 11% and 34%, respectively. Indomethacin caused a reduction in ICP within 15 s during both anesthetic regimens, with the decrease in ICP being significantly more pronounced during isoflurane (P = 0.009). In both anesthetic groups, indomethacin caused a simultaneous increase in mean arterial blood pressure and a further 17% versus 14% decrease in CBF from predrug values for isoflurane and propofol, respectively. The reduction in CBF was significantly more pronounced for propofol (P = 0.02). The effect on ICP, however, was most pronounced during isoflurane anesthesia. We suggest that the effect of indomethacin is partly mediated by an autoregulatory response.
Keywords: Animals; Sheep; Intracranial Hypertension; Isoflurane; Propofol; Indomethacin; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthesia, Inhalation; Blood Pressure; Cerebrovascular Circulation; Intracranial Pressure; Female
Description: Copyright © 2006 by the International Anesthesia Research Society.
RMID: 0020060706
DOI: 10.1213/01.ane.0000204259.88592.dd
Appears in Collections:Anaesthesia and Intensive Care publications

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