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Type: Journal article
Title: Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide
Author: Lewanowitsch, T.
Miller, J.
Irvine, R.
Citation: Life Sciences, 2006; 78(7):682-688
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2006
ISSN: 0024-3205
Statement of
Tanya Lewanowitsch, John H. Miller and Rodney J. Irvine
Abstract: Opioid overdose, which is commonly associated with opioid induced respiratory depression, is a problem with both therapeutic and illicit opioid use. While the central mechanisms involved in the effects of opioids are well described, it has also been suggested that a peripheral component may contribute to the effects observed. This study aimed to further characterise the effects of the peripherally acting naloxone methiodide on the respiratory, analgesic and withdrawal effects produced by various opioid agonists. A comparison of the respiratory and analgesic effects of morphine, methadone and heroin in male Swiss–Albino mice was conducted and respiratory depressive ED80 doses of each opioid determined. These doses (morphine 9 mg/kg i.p., methadone 7 mg/kg i.p., and heroin 17 mg/kg i.p.) were then used to show that both naloxone (3 mg/kg i.p.) and naloxone methiodide (30–100 mg/kg i.p.) could reverse the respiratory and analgesic effects of these opioid agonists, but only naloxone precipitated withdrawal. Further investigation in female C57BL/6J mice using barometric plethysmography found that both opioid antagonists could reverse methadone induced decreases in respiratory rate and increases in tidal volume. Its effects do not appear to be strain or sex dependent. It was concluded that naloxone methiodide can reverse the respiratory and analgesic actions of a variety of opioid agonists, without inducing opioid withdrawal.
Keywords: Naloxone Methiodide; respiratory depression; analgesia; opioid withdrawal
RMID: 0020060275
DOI: 10.1016/j.lfs.2005.05.062
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Appears in Collections:Pharmacology publications

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