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https://hdl.handle.net/2440/23150
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dc.contributor.author | Gibson, C. | - |
dc.contributor.author | MacLennan, A. | - |
dc.contributor.author | Goldwater, P. | - |
dc.contributor.author | Haan, E. | - |
dc.contributor.author | Priest, K. | - |
dc.contributor.author | Dekker, G. | - |
dc.contributor.author | Hague, W. | - |
dc.contributor.author | Morton, M. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | American Journal of Obstetrics and Gynecology, 2006; 194(3):674e1-674e11 | - |
dc.identifier.issn | 0002-9378 | - |
dc.identifier.issn | 1097-6868 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23150 | - |
dc.description.abstract | Objective The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. Study design This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor–alpha-308, mannose-binding lectin–221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. Results At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor– α (odds ratio, 1.82; 95% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon–1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor– α was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95% CI, 1.02-1.84). Conclusion Carriage of polymorphisms in the tumor necrosis factor– α and mannose-binding lectin genes are associated with an increased risk of cerebral palsy. | - |
dc.description.statementofresponsibility | Catherine S. Gibson, Alastair H. MacLennan, Paul N. Goldwater, Eric A. Haan, Kevin Priest, Gustaaf A. Dekker | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description | - |
dc.language.iso | en | - |
dc.publisher | Mosby Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ajog.2006.01.093 | - |
dc.subject | Cerebral palsy | - |
dc.subject | Tumor necrosis factor–α | - |
dc.subject | Mannose-binding lectin | - |
dc.subject | Polymorphism | - |
dc.title | The association between inherited cytokine polymorphisms and cerebral palsy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ajog.2006.01.093 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Goldwater, P. [0000-0003-4822-8488] | - |
dc.identifier.orcid | Haan, E. [0000-0002-7310-5124] | - |
dc.identifier.orcid | Dekker, G. [0000-0002-7362-6683] | - |
dc.identifier.orcid | Hague, W. [0000-0002-5355-2955] | - |
Appears in Collections: | Aurora harvest 6 Cerebral Palsy Research Group publications Obstetrics and Gynaecology publications |
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