Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23193
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDe Blasio, M.en
dc.contributor.authorGatford, K.en
dc.contributor.authorRobinson, J.en
dc.contributor.authorOwens, J.en
dc.date.issued2007en
dc.identifier.citationAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2007; 292(2):875-886en
dc.identifier.issn0363-6119en
dc.identifier.issn1522-1490en
dc.identifier.urihttp://hdl.handle.net/2440/23193-
dc.description.abstractIntrauterine growth restriction (IUGR) is associated with accelerated growth after birth. Together, IUGR and accelerated growth after birth predict reduced lean tissue mass and increased obesity in later life. Although placental insufficiency is a major cause of IUGR, whether it alters growth and adiposity in early postnatal life is not known. We hypothesized that placental restriction (PR) in the sheep would reduce size at birth and increase postnatal growth rate, fat mass, and feeding activity in the young lamb. PR reduced survival rate and size at birth, with soft tissues reduced to a greater extent than skeletal tissues and relative sparing of head width (P < 0.05 for all). PR did not alter absolute growth rates (i.e., the slope of the line of best fit for age vs. parameter size from birth to 45 days of age) but increased neonatal fractional growth rates (absolute growth rate relative to size at birth) for body weight (+24%), tibia (+15%) and metatarsal (+18%) lengths, hindlimb (+23%) and abdominal (+19%) circumferences, and fractional growth rates for current weight (P < 0.05) weekly throughout the first 45 days of life. PR and small size at birth reduced individual skeletal muscle weights and increased visceral adiposity in absolute and relative terms. PR also altered feeding activity, which increased with decreasing size at birth and was predictive of increased postnatal growth and adiposity. In conclusion, PR reduced size at birth and induced catch-up growth postnatally, normalizing weight and length but increasing adiposity in early postnatal life. Increased feeding activity may contribute to these alterations in growth and body composition following prenatal restraint and, if they persist, may lead to adverse metabolic and cardiovascular outcomes in later life.en
dc.description.statementofresponsibilityMiles J. De Blasio, Kathryn L. Gatford, Jeffrey S. Robinson and Julie A. Owensen
dc.language.isoenen
dc.publisherAmer Physiological Socen
dc.rightsCopyright © 2007 by the American Physiological Society.en
dc.subjectAdiposity; fetal growth restriction; catch-up growthen
dc.titlePlacental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity and adiposity in the young lamben
dc.typeJournal articleen
dc.identifier.rmid0020061342en
dc.identifier.doi10.1152/ajpregu.00430.2006en
dc.identifier.pubid52343-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]en
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.