Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/23197
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Endogenous inhibitors of nitric oxide and preeclampsia: A review |
Author: | Slaghekke, F. Dekker, G. Jeffries, W. |
Citation: | The Journal of Maternal-Fetal and Neonatal Medicine, 2006; 19(8):447-452 |
Publisher: | Taylor & Francis Ltd |
Issue Date: | 2006 |
ISSN: | 1476-7058 1476-4954 |
Statement of Responsibility: | Femke Slaghekke, Gus Dekker, Bill Jeffries |
Abstract: | Nitric oxide (NO) is a potent vasodilator. NO is synthesized by NO synthases (NOS) and NOS are inhibited by asymmetrical dimethylarginine (ADMA). ADMA is metabolized by dimethylarginine dimethylaminohydrolase (DDAH) and excreted in the kidneys. Lower ADMA levels in pregnant women compared to non-pregnant controls suggest that ADMA has a role in vascular dilatation and blood pressure changes. Several studies show an increase in ADMA levels in pregnancies complicated with preeclampsia. Elevated ADMA levels in preeclampsia are seen before clinical symptoms have developed; these findings suggest that ADMA has a role in the pathogenesis of preeclampsia. |
Keywords: | endogenous inhibitors asymmetric dimethylarginine (ADMA) nitric oxide (NO) pregnancy preeclampsia |
DOI: | 10.1080/14767050600852171 |
Published version: | http://dx.doi.org/10.1080/14767050600852171 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.