Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23309
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dc.contributor.authorCohen, R.en
dc.contributor.authorGrieve, S.en
dc.contributor.authorHoth, K.en
dc.contributor.authorPaul, R.en
dc.contributor.authorSweet, L.en
dc.contributor.authorTate, D.en
dc.contributor.authorGunstad, J.en
dc.contributor.authorStroud, L.en
dc.contributor.authorMcCaffery, J.en
dc.contributor.authorHitsman, B.en
dc.contributor.authorNiaura, R.en
dc.contributor.authorClark, C.en
dc.contributor.authorMcFarlane, A.en
dc.contributor.authorBryant, R.en
dc.contributor.authorGordon, E.en
dc.contributor.authorWilliams, L.en
dc.date.issued2006en
dc.identifier.citationBiological Psychiatry, 2006; 59(10):975-982en
dc.identifier.issn0006-3223en
dc.identifier.issn1873-2402en
dc.identifier.urihttp://hdl.handle.net/2440/23309-
dc.descriptionCopyright © 2006 Society of Biological Psychiatry Published by Elsevier Inc.en
dc.description.abstractBackground Early life stress (ELS) is linked to adult psychopathology and may contribute to long-term brain alterations, as suggested by studies of women who suffered childhood sexual abuse. We examine whether reported adverse ELS defined as stressful and/or traumatic adverse childhood events (ACEs) is associated with smaller limbic and basal ganglia volumes. Method 265 healthy Australian men and women without psychopathology or brain disorders were studied. ACEs were assessed by the ELSQ and current emotional state by the DASS. Anterior cingulate cortex (ACC), hippocampus, amygdala, and caudate nucleus volumes were measured from T1-weighted MRI. Analyses examined ROI volumetric associations with reported ACEs and DASS scores. Results Participants with greater than two ACEs had smaller ACC and caudate nuclei than those without ACEs. A significant association between total ACEs and ROI volumes for these structures was observed. Regression analysis also revealed that ELS was more strongly associated than current emotional state (DASS) with these ROI volumes. Conclusions Reported ELS is associated with smaller ACC and caudate volumes, but not the hippocampal or amygdala volumes. The reasons for these brain effects are not entirely clear, but may reflect the influence of early stress and traumatic events on the developing brain.en
dc.description.statementofresponsibilityRonald A. Cohen, Stuart Grieve, Karin F. Hoth, Robert H. Paul, Lawrence Sweet, David Tate, John Gunstad, Laura Stroud, Jeanne McCaffery, Brian Hitsman, Raymond Niaura, C. Richard Clark, Alexander MacFarlane, Richard Bryant, Evian Gordon, and Leanne M. Williamsen
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505750/description#descriptionen
dc.language.isoenen
dc.publisherElsevier Science Incen
dc.subjectearly life stress; adverse childhood events; brain morphometry; anterior cingulate cortex; caudate nucleus; amygdala; hippocampus; MRIen
dc.titleEarly life stress and morphometry of the adult anterior cingulate cortex and caudate nucleien
dc.typeJournal articleen
dc.identifier.rmid0020060557en
dc.identifier.doi10.1016/j.biopsych.2005.12.016en
dc.identifier.pubid52904-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Psychiatry publications

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