Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/23840
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Extreme population-dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare |
Author: | Caldwell, K. Russell, J. Langridge, P. Powell, W. |
Citation: | Genetics: a periodical record of investigations bearing on heredity and variation, 2006; 172(1):557-567 |
Publisher: | Genetics |
Issue Date: | 2006 |
ISSN: | 0016-6731 0016-6731 |
Statement of Responsibility: | Katherine S. Caldwell, Joanne Russell, Peter Langridge, and Wayne Powell |
Abstract: | In human genetics a detailed knowledge of linkage disequilibrium (LD) is considered a prerequisite for effective population-based, high-resolution gene mapping and cloning. Similar opportunities exist for plants; however, differences in breeding system and population history need to be considered. Here we report a detailed study of localized LD in different populations of an inbreeding crop species. We measured LD between and within four gene loci within the region surrounding the hardness locus in three different gene pools of barley (Hordeum vulgare). We demonstrate that LD extends to at least 212 kb in elite barley cultivars but is rapidly eroded in related inbreeding ancestral populations. Our results indicate that haplotype-based sequence analysis in multiple populations will provide new opportunities to adjust the resolution of association studies in inbreeding crop species. |
Keywords: | Chromosomes, Plant Hordeum Inbreeding Genetics, Population Haplotypes Linkage Disequilibrium Polymorphism, Single Nucleotide Genome, Plant Molecular Sequence Data Genetic Variation Selection, Genetic |
DOI: | 10.1534/genetics.104.038489 |
Published version: | http://dx.doi.org/10.1534/genetics.104.038489 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 2 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.