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https://hdl.handle.net/2440/23978
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Type: | Journal article |
Title: | Designer probiotics for prevention of enteric infections |
Author: | Paton, A. Morona, R. Paton, J. |
Citation: | Nature Reviews Microbiology, 2006; 4(3):193-200 |
Publisher: | Nature Publishing Group |
Issue Date: | 2006 |
ISSN: | 1740-1526 1740-1534 |
Statement of Responsibility: | Adrienne W. Paton, Renato Morona and James C. Paton |
Abstract: | Many microbial pathogens, including those responsible for major enteric infections, exploit oligosaccharides that are displayed on the surface of host cells as receptors for toxins and adhesins. Blocking crucial ligand–receptor interactions is therefore a promising therapeutic strategy. One approach is to express molecular mimics of host receptors on the surface of harmless recombinant bacteria that can survive in the gut. These ‘designer probiotics’ bind bacterial toxins in the gut lumen with very high avidity, thereby preventing disease. This article discusses recent progress with this strategy. |
Keywords: | Animals Bacteria Gastroenteritis Oligosaccharides Adhesins, Bacterial Receptors, Cell Surface Bacterial Toxins Species Specificity Molecular Mimicry Drug Design Probiotics |
Description: | © 2007 Nature Publishing Group |
DOI: | 10.1038/nrmicro1349 |
Published version: | http://dx.doi.org/10.1038/nrmicro1349 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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