Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/2915
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Type: Journal article
Title: Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women
Author: Farnsworth, E.
Luscombe-Marsh, N.
Noakes, M.
Wittert, G.
Argyiou, E.
Clifton, P.
Citation: American Journal of Clinical Nutrition, 2003; 78(1):31-39
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2003
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Emma Farnsworth, Natalie D Luscombe, Manny Noakes, Gary Wittert, Eleni Argyiou and Peter M Clifton
Abstract: It is not clear whether varying the protein-to-carbohydrate ratio of weight-loss diets benefits body composition or metabolism.The objective was to compare the effects of 2 weight-loss diets differing in protein-to-carbohydrate ratio on body composition, glucose and lipid metabolism, and markers of bone turnover.A parallel design included either a high-protein diet of meat, poultry, and dairy foods (HP diet: 27% of energy as protein, 44% as carbohydrate, and 29% as fat) or a standard-protein diet low in those foods (SP diet: 16% of energy as protein, 57% as carbohydrate, and 27% as fat) during 12 wk of energy restriction (6-6.3 MJ/d) and 4 wk of energy balance ( approximately 8.2 MJ/d). Fifty-seven overweight volunteers with fasting insulin concentrations > 12 mU/L completed the study.Weight loss (7.9 +/- 0.5 kg) and total fat loss (6.9 +/- 0.4 kg) did not differ between diet groups. In women, total lean mass was significantly (P = 0.02) better preserved with the HP diet (-0.1 +/- 0.3 kg) than with the SP diet (-1.5 +/- 0.3 kg). Those fed the HP diet had significantly (P < 0.03) less glycemic response at weeks 0 and 16 than did those fed the SP diet. After weight loss, the glycemic response decreased significantly (P < 0.05) more in the HP diet group. The reduction in serum triacylglycerol concentrations was significantly (P < 0.05) greater in the HP diet group (23%) than in the SP diet group (10%). Markers of bone turnover, calcium excretion, and systolic blood pressure were unchanged.Replacing carbohydrate with protein from meat, poultry, and dairy foods has beneficial metabolic effects and no adverse effects on markers of bone turnover or calcium excretion.
Keywords: Humans; Hyperinsulinism; Insulin Resistance; Obesity; Blood Glucose; Lipids; Fatty Acids, Nonesterified; Triglycerides; Dietary Proteins; Diet; Body Composition; Energy Intake; Middle Aged; Female; Male; Cholesterol, LDL; Cholesterol, HDL
Description: Copyright © 2003 American Society for Clinical Nutrition
RMID: 0020030146
DOI: 10.1093/ajcn/78.1.31
Published version: http://www.ajcn.org/cgi/content/abstract/78/1/31
Appears in Collections:Molecular and Biomedical Science publications
Medicine publications

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