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https://hdl.handle.net/2440/2972
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Type: | Journal article |
Title: | -308 Nco I polymorphism of tumour necrosis factor a in overweight caucasians |
Author: | Coates, A. Heilbronn, L. Noakes, M. Kind, K. Clifton, P. |
Citation: | Diabetes Research and Clinical Practice, 2003; 62(3):197-201 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2003 |
ISSN: | 0168-8227 1872-8227 |
Statement of Responsibility: | Alison M. Morris, Leonie K. Heilbronn, Manny Noakes, Karen L. Kind and Peter M. Clifton |
Abstract: | We investigated whether a polymorphism in the promoter region of the TNFα gene (−308 A/G) is associated with reduced weight loss in obese Australian subjects on an energy restricted diet. 189 healthy subjects and 91 subjects with type II diabetes were genotyped for the −308 Nco I polymorphism using PCR-RFLP techniques. A subset of these subjects (211 females and 45 males), were placed on a 30% energy restricted diet (6200 kJ) for 12 weeks. Subjects were assessed every 2 weeks and changes in body weight, waist circumference and BMI were used as determinants of weight loss. Fasting plasma was analysed for glucose, insulin, lipids and free fatty acids. 64% of subjects were GG homozygotes, 31% were AG heterozygotes and 5% were AA homozygotes. There was no significant difference between the allele frequency in healthy subjects (0.21) and type 2 diabetic patients (0.24). The presence of the −308 A/G polymorphism did not significantly influence initial BMI, the amount of weight lost (GG, 8.1±0.65 kg, AG, 6.9±0.77 kg, AA, 7.6±0.12 kg), waist circumference or any metabolic variable. The AA variant at position −308 in the promoter region of the TNFα gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet. |
Keywords: | Tumour necrosis factor alpha polymorphism obesity weight loss |
DOI: | 10.1016/j.diabres.2003.08.002 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/505949/description#description |
Published version: | http://dx.doi.org/10.1016/j.diabres.2003.08.002 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 Molecular and Biomedical Science publications |
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