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https://hdl.handle.net/2440/32699
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Type: | Journal article |
Title: | Glycine toxicity and unexpected intra-operative death |
Author: | Byard, R. Harrison, R. Wells, R. Gilbert, J. |
Citation: | Journal of Forensic Sciences, 2001; 46(5):1244-1246 |
Publisher: | Amer Soc Testing Materials |
Issue Date: | 2001 |
ISSN: | 0022-1198 1556-4029 |
Abstract: | A rare complication of the use of glycine irrigation fluid during prostatic surgery in a 69-year-old man is described. Following cystolithopexy and transurethral resection of the prostate for benign prostatomegaly, abdominal distension developed with increasing ventilatory pressures. Despite retroperitoneal fluid evacuation at subsequent urgent laparotomy, cardiac arrest occurred that was not amenable to resuscitation. At autopsy a traumatic defect in the posterior bladder wall filled with calculus debris was confirmed that did not communicate with the peritoneal cavity. Hyponatremia with markedly elevated levels of blood, urine, and body fluid glycine were demonstrated. Death was, therefore, attributed to glycine toxicity following tracking of glycine through a surgical defect in the posterior bladder wall. Careful dissection of surgical sites is required in such cases to demonstrate any additional trauma that may be associated with the fatal episode. Analysis of body fluids for glycine and electrolytes is also necessary to assist in the determination of possible mechanisms of death. |
Keywords: | Humans Prostatic Hyperplasia Heart Arrest Hyponatremia Syndrome Intraoperative Complications Glycine Prostatectomy Autopsy Cause of Death Fatal Outcome Peritoneal Lavage Forensic Medicine Aged Male Urinary Bladder |
Rights: | © 1997 Institute for Scientific Information |
DOI: | 10.1520/jfs15130j |
Published version: | http://dx.doi.org/10.1520/jfs15130j |
Appears in Collections: | Aurora harvest Pathology publications |
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