Tumour Suppressor Gene

Abstract

The invention provides an isolated DNA molecule comprising the nucleotide sequence set forth in SEQ ID NO: 1 or 2, or active fragments thereof, which encode a polypeptide active in suppressing cellular functions associated with cancer. In particular, the polypeptide (MTG16) functions as a tumour suppressor gene. It also provides variants of such DNA molecules which retain their function, polypeptides encoded by the DNA molecules and antibodies thereto, as well as the use of these molecules in diagnostic, prognostic and therapeutic procedures and other uses such as screening for candidate pharmaceuticals and animal model generation.