Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/34624
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Type: Journal article
Title: 8 prenylnaringenin novel phytoestrogen, inhibits angiogenesis in vitro and vivo.
Author: Pepper, M.
Hazel, S.
Humpel, M.
Schleuning, W.
Citation: Journal of Cellular Physiology, 2004; 199(1):98-107
Publisher: Wiley-Liss
Issue Date: 2004
ISSN: 0021-9541
1097-4652
Statement of
Responsibility: 
Michael S. Pepper, Susan J. Hazel, Michael Hümpel, Wolf-Dieter Schleuning
Abstract: 8-Prenylnaringenin is a recently discovered phytoestrogen. Using an in vitro model of angiogenesis in which endothelial cells can be induced to invade a three-dimensional collagen gel within which they form capillary-like tubes, we demonstrate that 8-prenylnaringenin inhibits angiogenesis induced by basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), or the synergistic effect of the two cytokines in combination, with an IC(50) of between 3 and 10 microM. This effect was seen with bovine microvascular endothelial cells derived from the adrenal cortex (BME cells) and with endothelial cells from the bovine thoracic aorta (BAE cells). The inhibitory effects of 8-prenylnaringenin were found to be roughly equipotent to those of genistein that has previously been shown to inhibit angiogenesis in vitro. Early chorioallantoic membrane (CAM) assay results showed reductions in both vessel lengths and vein diameters, with similar potency in the 8-prenylnaringenin and genistein groups. Similar effects on the CAM vessels were seen when the two substances were co-added. These findings suggest that 8-prenylnaringenin has potential therapeutic applications for diseases in which angiogenesis is an important component.
Keywords: Allantois
Chorion
Cells, Cultured
Endothelial Cells
Animals
Humans
Flavanones
Isoflavones
Genistein
Growth Inhibitors
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Recombinant Proteins
Plant Preparations
Phytoestrogens
Neovascularization, Physiologic
In Vitro Techniques
DOI: 10.1002/jcp.10460
Published version: http://dx.doi.org/10.1002/jcp.10460
Appears in Collections:Agriculture, Food and Wine publications
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