Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34682
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Type: Journal article
Title: Catheter ablation for atrial fibrillation in congestive heart failure
Author: Hsu, L.
Jais, P.
Sanders, P.
Garrigue, S.
Hocini, M.
Sacher, F.
Takahashi, Y.
Rotter, M.
Pasquie, J.
Scavee, C.
Bordachar, P.
Clementy, J.
Haissaguerre, M.
Citation: New England Journal of Medicine, 2004; 351(23):2373-2383
Publisher: Massachusetts Medical Soc
Issue Date: 2004
ISSN: 0028-4793
1533-4406
Statement of
Responsibility: 
Li-Fern Hsu, Pierre Jaïs, Prashanthan Sanders, Stéphane Garrigue, Mélèze Hocini, Fréderic Sacher, Yoshihide Takahashi, Martin Rotter, Jean-Luc Pasquié, Christophe Scavée, Pierre Bordachar, Jacques Clémenty, and Michel Haïssaguerre
Abstract: Background - Congestive heart failure and atrial fibrillation often coexist, and each adversely affects the other with respect to management and prognosis. We prospectively evaluated the effect of catheter ablation for atrial fibrillation on left ventricular function in patients with heart failure. Methods - We studied 58 consecutive patients with congestive heart failure and a left ventricular ejection fraction of less than 45 percent who were undergoing catheter ablation for atrial fibrillation. We selected as controls 58 patients without congestive heart failure who were undergoing ablation for atrial fibrillation, matched according to age, sex, and classification of atrial fibrillation. We evaluated the patients' left ventricular function and dimensions, symptom score, exercise capacity, and quality of life at baseline and at months 1, 3, 6, and 12. Results - After a mean (±SD) of 12±7 months, 78 percent of the patients with congestive heart failure and 84 percent of the controls remained in sinus rhythm (P=0.34) (69 percent and 71 percent, respectively, were in sinus rhythm without the administration of antiarrhythmic drugs). The patients with congestive heart failure had significant improvement in left ventricular function (increases in the ejection fraction and fractional shortening of 21±13 percent and 11±7 percent, respectively; P<0.001 for both comparisons), left ventricular dimensions (decreases in the diastolic and systolic diameters of 6±6 mm and 8±7 mm, respectively; P=0.03 and P<0.001, respectively), exercise capacity, symptoms, and quality of life. The ejection fraction improved significantly not only in patients without concurrent structural heart disease (24±10 percent, P<0.001) and those with inadequate rate control before ablation (23±10 percent, P<0.001), but also in those with coexisting heart disease (16±14 percent, P<0.001) and adequate rate control before ablation (17±15 percent, P<0.001). Conclusions - Restoration and maintenance of sinus rhythm by catheter ablation without the use of drugs in patients with congestive heart failure and atrial fibrillation significantly improve cardiac function, symptoms, exercise capacity, and quality of life.
Keywords: Humans; Heart Diseases; Atrial Fibrillation; Stroke Volume; Catheter Ablation; Case-Control Studies; Follow-Up Studies; Prospective Studies; Heart Rate; Exercise Tolerance; Quality of Life; Aged; Female; Male; Heart Failure
Description: © 2004 Massachusetts Medical Society.
RMID: 0020063335
DOI: 10.1056/NEJMoa041018
Published version: http://content.nejm.org/cgi/content/abstract/351/23/2373
Appears in Collections:Medicine publications

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