Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34683
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Type: Journal article
Title: Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome
Author: Haissaguerre, M.
Sanders, P.
Hocini, M.
Hsu, L.
Shah, D.
Scavee, C.
Takahashi, Y.
Rotter, M.
Pasquie, J.
Garrigue, S.
Clementy, J.
Jais, P.
Citation: Circulation, 2004; 109(24):3007-3013
Publisher: Lippincott Williams & Wilkins
Issue Date: 2004
ISSN: 0009-7322
1524-4539
Statement of
Responsibility: 
Michel Haïssaguerre, Prashanthan Sanders, Mélèze Hocini, Li-Fern Hsu, Dipen C. Shah, Christophe Scavée, Yoshihide Takahashi, Martin Rotter, Jean-Luc Pasquié, Stéphane Garrigue, Jacques Clémenty, and Pierre Jaïs
Abstract: BACKGROUND: The modification of atrial fibrillation cycle length (AFCL) during catheter ablation in humans has not been evaluated. METHODS AND RESULTS: Seventy patients undergoing ablation of prolonged episodes of AF were randomized to pulmonary vein (PV) isolation or additional ablation of the mitral isthmus. Mean AFCL was determined at a distance from the ablated area (coronary sinus) at the following intervals: before ablation, after 2- and 4-PV isolations, and after linear ablation. Inducibility of sustained AF (> or =10 minutes) was determined before and after ablation. Spontaneous sustained AF (715+/-845 minutes) was present in 30 patients and induced in 26 (AFCL, 186+/-19 ms). PV isolation terminated AF in 75%, with the number of PVs requiring isolation before termination increasing with AF duration (P=0.018). PV isolation resulted in progressive or abrupt AFCL prolongation to various extents, depending on the PV: to 214+/-24 ms (P<0.0001) when AF terminated and to 194+/-19 ms (P=0.002) when AF persisted. The increase in AFCL (30+/-17 versus 14+/-11 ms; P=0.005) and the decrease in fragmentation (30.0+/-26.8% to 10.3+/-14.5%; P<0.0001) were significantly greater in patients with AF termination. Linear ablation prolonged AFCL, with a greater prolongation in patients with AF termination (44+/-13 versus 22+/-23 ms; P=0.08). Sustained AF was noninducible in 57% after PV isolation and in 77% after linear ablation. At 7+/-3 months, 74% with PV isolation and 83% with linear ablation were arrhythmia free without antiarrhythmics, which was significantly associated with noninducibility (P=0.03) with a recurrence rate of 38% and 13% in patients with and without inducibility, respectively. CONCLUSIONS: AF ablation results in a decline in AF frequency, with a magnitude correlating with termination of AF and prevention of inducibility that is predictive of subsequent clinical outcome.
Keywords: arrhythmia; cardioversion; drugs; electrophysiology; surgery
Description: © 2004 American Heart Association, Inc.
RMID: 0020063338
DOI: 10.1161/01.CIR.0000130645.95357.97
Appears in Collections:Medicine publications

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