Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/35674
Citations
Scopus Web of Science® Altmetric
?
?
Type: Conference paper
Title: The temporal profile of edema formation differs between male and female rats following diffuse traumatic brain injury
Author: O'Connor, C.
Cernak, I.
Vink, R.
Citation: Brain edema XIII / J.T. Hoff ... [et al.] (eds.): pp.121-124
Publisher: Springer
Publisher Place: New York
Issue Date: 2006
Series/Report no.: Acta neurochirurgica Supplement ; 96
ISBN: 3211307125
9783211307120
ISSN: 0065-1419
Conference Name: International Symposium on Brain Edema and Tissue Injury (13th : 2005 : Ann Arbor, Mich.)
Editor: Hoff, J.
Keep, R.
Xi, G.
Hua, Y.
Statement of
Responsibility: 
C. A. O’Connor, I. Cernak, R. Vink
Abstract: Although female hormones are known to influence edema formation following traumatic brain injury (TBI), no studies have actually compared the temporal profile of edema formation in both male and female rats following diffuse TBI. In this study, male, female, and female ovariectomized rats were injured using the 2 m impact acceleration model of diffuse TBI. The temporal profile of brain water content was assessed over 1 week post-trauma. Male animals demonstrated increased (p < 0:05) edema at 5 hours, 24 hours, 3 days, 4 days, and 5 days after TBI with a peak at 5 hours post-injury. This time point was associated with increased blood-brain barrier (BBB) permeability. In contrast, intact females showed increased levels of edema (p < 0:05) at 5 hours, 24 hours, 3 days, and 4 days post-TBI, with a peak at 24 hours. No BBB opening was present in intact females at 5 hours. Female animals demonstrated more edema than male animals at 24 hours, but less at 5 hours, 3 days, and 5 days. Ovariectomy produced an edema profile that was similar to that observed in males. The temporal profile of edema formation after TBI seems to depend on endogenous hormone levels, a difference which may have an influence on clinical management.
Keywords: Blood-Brain Barrier
Animals
Rats
Rats, Sprague-Dawley
Brain Edema
Brain Injuries
Disease Models, Animal
Ovariectomy
Sex Factors
Time Factors
Female
Male
Rights: © 2006 Springer-Verlag/Wien
DOI: 10.1007/3-211-30714-1_27
Published version: http://dx.doi.org/10.1007/3-211-30714-1_27
Appears in Collections:Aurora harvest 6
Pathology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.