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dc.contributor.authorWalther, T.en
dc.contributor.authorWessel, N.en
dc.contributor.authorBaumert, M.en
dc.contributor.authorStepan, H.en
dc.contributor.authorVoss, A.en
dc.contributor.authorFaber, R.en
dc.date.issued2005en
dc.identifier.citationHypertension Research, 2005; 28(2):113-118en
dc.identifier.issn0916-9636en
dc.identifier.issn1348-4214en
dc.identifier.urihttp://hdl.handle.net/2440/36604-
dc.descriptionCopyright © 2005 by the Japanese Society of Hypertensionen
dc.description.abstractIn the US, it is currently estimated that 3% of pregnant women have chronic hypertension, or more than 100,000 pregnant women each year. The aim of our study was to investigate the adaptation of autonomic control during pregnancy based on heart rate variability analysis and to determine whether chronic hypertension during pregnancy has an impact on this adaptation. Sixteen pregnant women with chronic hypertension (CH group; mean age, 30 years; range, 25-33 years) and 35 healthy pregnant women serving as controls (CON group; mean age, 28 years; range, 24-30 years) were recruited for this longitudinal study. Beginning at the 20th week of pregnancy, the women were monitored every 4th week until delivery. For the analysis of heart rate variability, Portapres signals (200 Hz) were recorded for 30 min under resting conditions. Women in the CH group had significantly elevated blood pressure compared to controls (CON, 111 mmHg [105-132]; CH, 140 mmHg [132-148]; p<0.001). An increased heart rate was found in both groups during the second half of pregnancy. Consequently, decreased heart rate variability was observed, but was more pronounced in the CON group. There was a shift in the frequency bands indicated by an elevation of the low-to-high frequency ratio (LF/HF) in both groups due to a decrease in HF, and thus a significant increase in LFn (LF power in normalized units). However, VLF (power of very low frequency range) increased exclusively in the CON pregnancies. Our data showed no significant difference in heart rate variability between the subjects of the CH and CON groups. Longitudinal variations were detectable in normal pregnancies and also, albeit to a lesser degree, in chronic hypertensive pregnant women. Thus, our data indicate that patients with long-term hypertension are still able to respond to the physiological changes occurring during pregnancy.en
dc.description.statementofresponsibilityThomas Walther, Niels Wessel, Mathias Baumert, Holger Stepan, Andreas Voss and Renaldo Faberen
dc.language.isoenen
dc.publisherJapanese Soc Hypertension Cent Academic Socen
dc.subjectheart rate variability; normotensive pregnancy; chronic hypertensive pregnancyen
dc.titleLongitudinal analysis of heart rate variability in chronic hypertensive pregnancyen
dc.typeJournal articleen
dc.identifier.rmid0020065519en
dc.identifier.doi10.1291/hypres.28.113en
dc.identifier.pubid49723-
pubs.library.collectionElectrical and Electronic Engineering publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidBaumert, M. [0000-0003-2984-2167]en
Appears in Collections:Electrical and Electronic Engineering publications

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