Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/37002
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dc.contributor.authorWillerslev, E.en
dc.contributor.authorCooper, A.en
dc.date.issued2005en
dc.identifier.citationProceedings of the Royal Society of London Series B-Biological Sciences, 2005; 272(1558):3-16en
dc.identifier.issn0962-8452en
dc.identifier.issn1471-2970en
dc.identifier.urihttp://hdl.handle.net/2440/37002-
dc.description© 2005 The Royal Society Review paperen
dc.description.abstractIn the past two decades, ancient DNA research has progressed from the retrieval of small fragments of mitochondrial DNA from a few late Holocene specimens, to large-scale studies of ancient populations, phenotypically important nuclear loci, and even whole mitochondrial genome sequences of extinct species. However, the field is still regularly marred by erroneous reports, which underestimate the extent of contamination within laboratories and samples themselves. An improved understanding of these processes and the effects of damage on ancient DNA templates has started to provide a more robust basis for research. Recent methodological advances have included the characterization of Pleistocene mammal populations and discoveries of DNA preserved in ancient sediments. Increasingly, ancient genetic information is providing a unique means to test assumptions used in evolutionary and population genetics studies to reconstruct the past. Initial results have revealed surprisingly complex population histories, and indicate that modern phylogeographic studies may give misleading impressions about even the recent evolutionary past. With the advent and uptake of appropriate methodologies, ancient DNA is now positioned to become a powerful tool in biological research and is also evolving new and unexpected uses, such as in the search for extinct or extant life in the deep biosphere and on other planets.en
dc.description.statementofresponsibilityEske Willerslev and Alan Cooperen
dc.language.isoenen
dc.publisherRoyal Soc Londonen
dc.subjectancient DNA; palaeontology; palaeoecology; archaeology; population genetics; DNA damage and repairen
dc.titleAncient DNAen
dc.typeJournal articleen
dc.identifier.rmid0020065909en
dc.identifier.doi10.1098/rspb.2004.2813en
dc.identifier.pubid49429-
pubs.library.collectionEarth and Environmental Sciences publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]en
Appears in Collections:Earth and Environmental Sciences publications
Australian Centre for Ancient DNA publications
Environment Institute Leaders publications

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