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https://hdl.handle.net/2440/37290
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dc.contributor.author | Callaghan, P. | - |
dc.contributor.author | Owens, W. | - |
dc.contributor.author | Javors, M. | - |
dc.contributor.author | Sanchez, T. | - |
dc.contributor.author | Jones, D. | - |
dc.contributor.author | Irvine, R. | - |
dc.contributor.author | Daws, L. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Neurochemistry, 2007; 100(3):617-627 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.issn | 1471-4159 | - |
dc.identifier.uri | http://hdl.handle.net/2440/37290 | - |
dc.description.abstract | p-Methoxyamphetamine (PMA) has been implicated in fatalities as a result of ‘ecstasy’ (MDMA) overdose worldwide. Like MDMA, acute effects are associated with marked changes in serotonergic neurotransmission, but the long-term effects of PMA are poorly understood. The aim of this study was to determine the effect of repeated PMA administration on in vitro measures of neurodegeneration: serotonin (5-HT) uptake, 5-HT transporter (SERT) density and 5-HT content in the hippocampus, and compare with effects on in vivo 5-HT clearance. Male rats received PMA, MDMA (4 or 15 mg/kg s.c., twice daily) or vehicle for 4 days and 2 weeks later indices of SERT function were measured. [3H]5-HT uptake into synaptosomes and [3H]cyanoimipramine binding to the SERT were significantly reduced by both PMA and MDMA treatments. 5-HT content was reduced in MDMA-, but not PMA-treatment. In contrast, clearance of locally applied 5-HT measured in vivo by chronoamperometry was only reduced in rats treated with 15 mg/kg PMA. The finding that 5-HT clearance in vivo was unaltered by MDMA treatment suggests that in vitro measures of 5-HT axonal degeneration do not necessarily predict potential compensatory mechanisms that maintain SERT function under basal conditions. | - |
dc.description.statementofresponsibility | Paul D. Callaghan, W. Anthony Owens, Martin A. Javors, Teresa A. Sanchez, David J. Jones, Rodney J. Irvine and Lynette C. Daws | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://www.blackwell-synergy.com/doi/abs/10.1111/j.1471-4159.2006.04247.x | - |
dc.subject | chronoamperometry | - |
dc.subject | 3, 4-methylenedioxymethamphetamine | - |
dc.subject | neurodegeneration | - |
dc.subject | para-methoxyamphetamine | - |
dc.subject | serotonin | - |
dc.subject | serotonin transporter | - |
dc.title | In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA) but not 3 4-methylenedioxymethamphetamine (MDMA) leads to long-lasting deficits in serotonin transporter function | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1471-4159.2006.04247.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Pharmacology publications |
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