Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/38926
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Type: Journal article
Title: Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation
Author: Kistler, P.
Sanders, P.
Dodic, M.
Spence, S.
Samuel, C.
Zhao, C.
Charles, J.
Edwards, G.
Kalman, J.
Citation: European Heart Journal, 2006; 27(24):3045-3056
Publisher: W B Saunders Co Ltd
Issue Date: 2006
ISSN: 0195-668X
1522-9645
Statement of
Responsibility: 
Peter M. Kistler, Prashanthan Sanders, Miodrag Dodic, Steven J. Spence, Chrishan S. Samuel, ChongXin Zhao, Jennifer A. Charles, Glenn A. Edwards, and Jonathan M. Kalman
Abstract: Aims Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure. Methods and results Twelve sheep with chronically EBP (mean arterial pressure 94+3 mmHg) and six controls (71+4 mmHg, P , 0.01) underwent acute open chest electrophysiologic and pathologic studies. We measured refractoriness at the atrial appendages at 3 cycle lengths (CL); conduction velocities at Bachmann’s bundle, both atrial appendages and free walls at 4 CLs; conduction heterogeneity; atrial wavelength and AF duration. We performed light microscopy (LM) and electron microscopy (EM) and collagen and apoptosis studies. EBP was associated with widespread conduction abnormalities, shortening of atrial wavelength, and increased AF. There was no significant change in refractoriness. LM demonstrated atrial myocyte hypertrophy and myolysis in all EBP sheep and focal scarring in six. EM demonstrated mitochondrial and nuclear enlargement and increased collagen fibrils in EBP sheep, findings not present in any controls. Atrial collagen and apoptosis were increased in EBP animals. Conclusion This study demonstrates that chronically, EBP is associated with significant atrial electrical and structural remodelling. These changes may explain the increased propensity to atrial arrhythmias observed with long-standing EBP.
Keywords: Hypertension; Atrium; Atrial fibrillation; Apoptosis
Description: © The European Society of Cardiology 2006. All rights reserved.
RMID: 0020071804
DOI: 10.1093/eurheartj/ehl360
Appears in Collections:Medicine publications

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