Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/38980
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Type: Journal article
Title: Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status
Author: Wittert, G.
Chapman, I.
Haren, M.
Mackintosh, S.
Coates, P.
Morley, J.
Citation: Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2003; 58(7):M618-M625
Publisher: Gerontological Society of America
Issue Date: 2003
ISSN: 1079-5006
1758-535X
Statement of
Responsibility: 
Gary A. Wittert, Ian M. Chapman, Matthew T. Haren, Shylie Mackintosh, Penelope Coates and John E. Morley
Abstract: BACKGROUND:Loss of muscle mass (sarcopenia) leads to frailty in older men. The decline in testosterone over the life span may contribute to this muscle loss. We studied the ability of oral testosterone to prevent muscle loss in older men over a 12-month period. METHODS:A standard dose (80 mg twice daily) of testosterone undecanoate or placebo was administered for 1 year to 76 healthy men aged 60 years or older. All men had a free testosterone index of 0.3-0.5, which represents a value below the normal lower limit for young men (19-30 years), but remains within the overall normal male range. Measurements of body composition, muscle strength, hormones, and safety parameters were obtained at 0, 6, and 12 months. RESULTS:Lean body mass increased (p =.0001) and fat mass decreased (p =.02) in the testosterone as compared with the placebo-treated group. There were no significant effects on muscle strength. There was a significant increase in hematocrit (0.02%) in the testosterone-treated group (p =.03). Plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels were similar in both groups, but there was a decrease in high-density lipoprotein cholesterol (-0.1 mmol/L) at 12 months in the testosterone group as compared to the placebo group (p = 0.026). There were no differences in prostate-specific antigen or systolic or diastolic blood pressure between the groups. CONCLUSION:Oral testosterone administration to older relatively hypogonadal men results in an increase in muscle mass and a decrease in body fat.
Keywords: Muscle, Skeletal; Genitalia, Male; Adipose Tissue; Humans; Testosterone; Gonadal Steroid Hormones; Prostate-Specific Antigen; Insulin-Like Growth Factor I; Androgens; Organ Size; Hand Strength; Hematocrit; Administration, Oral; Double-Blind Method; Body Composition; Diuresis; Aged; Aged, 80 and over; Middle Aged; Male; Cholesterol, HDL
Rights: Copyright © 2003 by The Gerontological Society of America
RMID: 0020071899
DOI: 10.1093/gerona/58.7.m618
Published version: http://biomed.gerontologyjournals.org/cgi/content/abstract/58/7/M618
Appears in Collections:Medicine publications

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