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https://hdl.handle.net/2440/39759
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Type: | Journal article |
Title: | Randomized trials with polyunsaturated fatty acid interventions in preterm and term infants: Functional and clinical outcomes |
Author: | Gibson, R. Chen, W. Makrides, M. |
Citation: | Lipids, 2001; 36(9):873-883 |
Publisher: | Amer Oil Chemists Soc A O C S Press |
Issue Date: | 2001 |
ISSN: | 0024-4201 1558-9307 |
Abstract: | The role of polyunsaturated fatty acids (PUFA) in infant nutrition has now been well studied through many randomized controlled trials (RCT) that provide us with high-quality evidence, particularly in relation to efficacy. As a result of a systematic search of the literature for RCT of supplementation of formulas of term and preterm infants with long-chain polyunsaturated fatty acids (LC-PUFA), we have identified 21 studies that have physiological responses or growth as outcomes. There have been 11 RCT involving preterm infants, and many of these claim a beneficial effect on visual, neural, or developmental outcomes. There are some reports of negative effects on growth in relation to the addition of n-3 LC-PUFA to preterm formulas but not when AA is added with n-3 LC-PUFA. Small studies have shown no differences in prostanoid formation or peroxidative stress between n-3 LC-PUFA-supplemented and unsupplemented infants. There have been 10 RCT involving term infants; whereas some studies report an effect on visual/neural/developmental outcomes, an equal number report no effect. There have been no reports of negative effects of n-3 LC-PUFA on growth in term infants. In summary, there appear to be few safety concerns relating to the use of LC-PUFA in infant nutrition. The potential medium- and long-term effects of including these compounds in the early diet of infants remain to be assessed. |
Keywords: | Humans alpha-Linolenic Acid Fatty Acids, Unsaturated Linoleic Acids Treatment Outcome Dietary Supplements Infant Food Infant, Newborn Infant, Premature Infant Nutritional Physiological Phenomena |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s11745-001-0797-2 |
Published version: | http://dx.doi.org/10.1007/s11745-001-0797-2 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 |
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