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Type: Conference paper
Title: Mild concussive head injury results in increased brain substance P immunoreactivity
Author: Donkin, J.
Cernak, I.
Rodgers, K.
Vink, R.
Citation: 7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.75-78
Publisher: Medimond International Proceedings
Publisher Place: Bologna, Italy
Issue Date: 2004
ISBN: 88-7587-082-9
Conference Name: International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.)
Statement of
J.J. Donkin, I. Cernak, K.M. Rodgers and R. Vink
Abstract: The neuroinflammatory neuropeptide substance P (SP) has been implicated in oedema development following traumatic brain injury. Whether the neuropeptide plays a role in concussive head injury is unknown. Accordingly, we have used a newly developed model of mild head injury in rats to characterise the release of SP following concussive brain injury. Following brain trauma, there was no evidence of motor or cognitive deficits over the ensuing 3 weeks. Despite this, increased SP immunoreactivity was present in perivascular axons, some pyramidal neurones and astrocytes when compared to sham animals. Our findings suggest that concussive brain injury predisposes an individual to diffuse brain swelling, which may have implications in the management of sports related concussion.
Description: The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included.
Rights: © 2004 by MEDIMOND
RMID: 0020075394
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Appears in Collections:Pathology publications

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