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https://hdl.handle.net/2440/41976
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Type: | Journal article |
Title: | Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects |
Author: | Chapman, I. Parker, B. Doran, S. Feinle-Bisset, C. Wishart, J. Lush, C. Chen, K. LaCerte, C. Burns, C. McKay, R. Weyer, C. Horowitz, M. |
Citation: | Obesity, 2007; 15(5):1179-1186 |
Publisher: | North Amer Assoc Study Obesity |
Issue Date: | 2007 |
ISSN: | 1930-7381 1930-739X |
Statement of Responsibility: | Ian Chapman, Barbara Parker, Selena Doran, Christine Feinle-Bisset, Judith Wishart, Cameron W. Lush, Kim Chen, Carl LaCerte, Colleen Burns, Robyn McKay, Christian Weyer and Michael Horowitz |
Abstract: | <h4>Objective</h4>We previously reported that a single preprandial injection (120 microg) of pramlintide, an analog of the beta-cell hormone amylin, reduced ad libitum food intake in obese subjects. To further characterize the meal-related effects of amylin signaling in humans, we studied a lower pramlintide dose (30 microg) in normal-weight subjects.<h4>Research methods and procedures</h4>In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions. After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal. After 1 hour, subjects were offered an ad libitum buffet meal, and total caloric intake and meal duration were measured.<h4>Results</h4>Compared with placebo, pramlintide reduced total caloric intake (1411 +/- 94 vs. 1190 +/- 117 kcal; Delta, -221 +/- 101 kcal; -14 +/- 9%; p = 0.05) and meal duration (36 +/- 2 vs. 31 +/- 3 minutes; Delta, -5.1 +/- 1.4 minutes; p < 0.005). Visual analog scale profiles of hunger trended lower and fullness higher during the first hour after pramlintide administration. In response to the buffet, hunger and fullness changed to a similar degree after pramlintide and placebo, despite subjects on pramlintide consuming 14% fewer kilocalories. Visual analog scale nausea ratings remained near baseline, without differences between treatments. Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.<h4>Discussion</h4>These observations add support to the concept that amylin agonism may have a role in human appetite control. |
Keywords: | peptide hormones buffet meal satiation hunger satiety |
DOI: | 10.1038/oby.2007.626 |
Published version: | http://dx.doi.org/10.1038/oby.2007.626 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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