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Type: Journal article
Title: Diet, acetylator phenotype, and risk of colorectal neoplasia
Author: Roberts-Thomson, I.
Ryan, P.
Khoo, K.
Hart, W.
McMichael, A.
Butler, R.
Citation: The Lancet, 1996; 347(9012):1372-1374
Publisher: Elsevier
Issue Date: 1996
ISSN: 0140-6736
Statement of
I.C. Roberts-Thomson, K.K. Khoo, W.J. Hart, R.N. Butler, P. Ryan, A.J. McMichael
Abstract: <h4>Background</h4>Inherited or acquired differences in metabolic pathways that activate or inactivate dietary carcinogens may influence the risk of developing cancer. A polymorphism in N-acetyltransferase classified people into fast and slow acetylators. This enzyme catalyses the formation of mutagenic products from foodstuffs, especially cooked meat and fish. Some data suggest that fast acetylators are at higher risk of colorectal cancer. We have studied the adenoma and cancer risk in relation to meat intake and acetylator status.<h4>Methods</h4>In a case-control study, we compared 110 patients with colorectal cancer, 89 patients with colorectal adenomatous polyps, and 110 controls. Acetylator status was assessed by the rate of acetylation of sulphamethazine given orally.<h4>Findings</h4>The fast-acetylator phenotype was associated with odds ratios of 1.1 (95% Cl 0.6-2.1) and 1.8 (1.0-3.3) for adenoma and colorectal cancer, respectively. The highest risk occurred in the youngest tertile (< 64 years) of cases (2.5 [0.7-9.4] and 8.9 [2.6-30.4], respectively). There was no difference between the sexes. The risk of adenoma or cancer increased with increasing intake of meat in fast but not in slow acetylators: covariate-adjusted odds of disease over three levels of meat consumption were 2.1 (0.9-4.7) for adenoma, 1.7 (0.9-3.5) for cancer, and 1.9 (1.0-3.7) for all tumours.<h4>Interpretation</h4>Our findings indicate that acetylator status modulates the risk of colorectal neoplasia associated with meat intake.
Keywords: Humans
Adenomatous Polyps
Colorectal Neoplasms
Arylamine N-Acetyltransferase
Risk Factors
Case-Control Studies
Aged, 80 and over
Middle Aged
Rights: © 1996 Published by Elsevier Ltd.
DOI: 10.1016/S0140-6736(96)91012-0
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