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https://hdl.handle.net/2440/42228
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dc.contributor.author | Brennan, I. | - |
dc.contributor.author | Otto, B. | - |
dc.contributor.author | Feltrin, K. | - |
dc.contributor.author | Meyer, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Peptides, 2007; 28(3):607-611 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.issn | 1873-5169 | - |
dc.identifier.uri | http://hdl.handle.net/2440/42228 | - |
dc.description | Copyright © 2006 Elsevier Inc. All rights reserved. | - |
dc.description.abstract | We have investigated the effects of exogenous CCK-8 and GLP-1, alone and in combination, on ghrelin and PYY secretion. Nine healthy males were studied on four occasions. Plasma ghrelin and PYY concentrations were measured during 150 min intravenous infusions of: (i) isotonic saline, (ii) CCK-8 at 1.8 pmol/kg/min, (iii) GLP-1 at 0.9 pmol/kg/min or (iv) CCK-8 and GLP-1 combined. CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t=0-120 min (P<0.001 for both). GLP-1 had no effect on ghrelin, but decreased PYY slightly at 120 min (P<0.05). During infusion of CCK-8+GLP-1, there was comparable suppression of ghrelin (P<0.001), but the stimulation of PYY was less (P<0.001), than that induced by CCK-8, between t=20-120 min. In conclusion, in healthy subjects, in the doses evaluated, exogenous CCK-8 suppresses ghrelin and stimulates PYY, and exogenous GLP-1 has no effect on ghrelin and attenuates the effect of CCK-8 on PYY. | - |
dc.description.statementofresponsibility | Ixchel M. Brennan, Bärbel Otto, Kate L. Feltrin, James H. Meyer, Michael Horowitz and Christine Feinle-Bisset | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/525495/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.peptides.2006.10.014 | - |
dc.subject | Humans | - |
dc.subject | Sincalide | - |
dc.subject | Peptide YY | - |
dc.subject | Peptide Hormones | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.subject | Ghrelin | - |
dc.title | Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.peptides.2006.10.014 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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