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Type: Journal article
Title: An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: Methodological considerations
Author: Horowitz, J.
Heresztyn, T.
Citation: Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 2007; 851(1-2):42-50
Publisher: Elsevier Science BV
Issue Date: 2007
ISSN: 1570-0232
Statement of
John D. Horowitz and Tamila Heresztyn
Abstract: Recent studies among patients including those with known coronary disease demonstrate that small elevations in asymmetric dimethylarginine (ADMA) concentrations in plasma are predictive of adverse outcomes. The precision of current methodologies for quantitation of ADMA such as HPLC, MS and ELISA is discussed with respect to many reports which appear to over-estimate ADMA levels and quote broad concentration ranges. While plasma ADMA concentrations tend to increase with age, the mean for a healthy population is between 0.4 and 0.6 microM. ADMA levels may fluctuate in normal subjects, and this needs to be considered in light of the relatively small differences in ADMA concentration between healthy normal subjects and patients.
Keywords: Animals; Humans; Disease; Arginine; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Health; Mass Spectrometry
Description: Copyright © 2006 Elsevier B.V. All rights reserved.
Provenance: Formerly known as Journal of Chromatography B: Biomedical Sciences and Applications
RMID: 0020070920
DOI: 10.1016/j.jchromb.2006.09.023
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Appears in Collections:Medicine publications

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