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https://hdl.handle.net/2440/43214
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Type: | Journal article |
Title: | The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep |
Author: | Boyce, A. Gibson, K. Wintour, E. Koukoulas, I. Gatford, K. Owens, J. Lumbers, E. |
Citation: | Canadian Journal of Physiology and Pharmacology, 2007; 85(6):597-605 |
Publisher: | Natl Research Council Canada |
Issue Date: | 2007 |
ISSN: | 0008-4212 1205-7541 |
Statement of Responsibility: | Amanda C. Boyce, Karen J. Gibson, E. Marelyn Wintour, Irene Koukoulas, Kathryn L. Gatford, Julie A. Owens, and Eugenie R. Lumbers |
Abstract: | We imposed a sustained reduction in glucose supply to late-gestation fetal sheep to see whether the reduction in glucose and insulin levels affected renal growth, renin expression and synthesis, and renal function. Maternal glucose concentrations were lowered to 1.7–1.9 mmol/L for 12–13 days by i.v. insulin infusion (n = 9, 121 days gestation, term = 150 days). Control ewes (n = 7) received vehicle. Maternal and fetal glucose concentrations were 40% and 31% lower than in controls (p < 0.001), respectively. Fetal plasma insulin levels fell 36% ± 7% by day 7 (p < 0.05); IGF-I levels were unchanged. Arterial PO2 and pH increased and PCO2 fell (p < 0.05). Renal function was largely unaffected. Longitudinal growth was 28% slower and spleen weights were 36% smaller (p < 0.05); body and kidney weights were not affected. Renal renin levels and renin, angiotensinogen, and angiotensin receptor mRNA levels were similar to those of controls. Plasma renin levels increased from 2.1 ± 0.6 to 7.6 ± 2.8 ng angiotensin I·mL–1·h–1 (p = 0.01). Thus reductions in fetal glucose and insulin levels in late gestation that were sufficient to retard skeletal growth had no effect on kidney growth or function or the renal renin–angiotensin system, possibly because IGF-I levels were not reduced. There was, however, increased activity of the circulating renin–angiotensin system similar to that seen during insulin-induced hypoglycaemia. |
Keywords: | Kidney Animals Sheep Hypoglycemia Chronic Disease Carbon Dioxide Oxygen Potassium Hydrocortisone Insulin Blood Glucose Somatomedins Insulin-Like Growth Factor Binding Proteins Hypoglycemic Agents Kidney Function Tests Organ Size Infusions, Intravenous Renin-Angiotensin System Fetal Development Gestational Age Pregnancy Heart Rate, Fetal Female |
Rights: | © 2007 NRC Canada |
DOI: | 10.1139/Y07-047 |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/17823621 |
Published version: | http://dx.doi.org/10.1139/y07-047 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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