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Type: Conference paper
Title: Effects of vagal blockade on the complexity of heart rate variability in rats
Author: Baumert, M.
Nalivaiko, E.
Abbott, D.
Citation: Proceedings of 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing (MEDICON ), as published in IFMBE Proceedings, 2007 / vol.16, iss.1, pp.26-29
Publisher: Springer-Verlag
Issue Date: 2007
Series/Report no.: IFMBE Proceedings
ISBN: 9783540730439
ISSN: 1680-0737
Conference Name: 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing (MEDICON ) (26 Jun 2007 - 30 Jun 2007 : Ljubljana, Slovenia)
Statement of
M. Baumert, E. Nalivaiko, and D. Abbott
Abstract: In this paper we investigate the influence of vagal blockage on heart rate variability complexity measures. Nine conscious rats are injected with methyl-scopolamine brobide (50 μg/kg s.c.). We analyze 10 minute segments of beat-to-beat intervals before and after injection by standard time and frequency domain methods, compression entropy, sample entropy, Poincaré plot, detrended fluctuation analysis and symbolic dynamics. All parameter domains show changes in heart rate variability after vagal blockade, indicating a decrease in heart rate complexity. In conclusion, vagal modulation plays an important role in the generation of heart complexity in rats or, in other words, heart rate complexity measures are sensitive to vagal heart rate modulation.
Keywords: heart rate variability; complexity; vagal blockade; rat
Rights: © Springer-Verlag Berlin Heidelberg 2007
RMID: 0020075332
DOI: 10.1007/978-3-540-73044-6_8
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Appears in Collections:Electrical and Electronic Engineering publications

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