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Type: Journal article
Title: Intervertebral disc degeneration reduces vertebral motion responses
Author: Colloca, C.
Keller, T.
Moore, R.
Gunzburg, R.
Harrison, D.
Citation: Spine, 2007; 32(19):E544-E550
Publisher: Lippincott Williams & Wilkins
Issue Date: 2007
ISSN: 0362-2436
Statement of
Colloca, Christopher J ; Keller, Tony S ; Moore, Robert J ; Gunzburg, Robert ; Harrison, Deed E
Abstract: STUDY DESIGN: A prospective in vivo experimental animal study. OBJECTIVE: To determine the effects of disc degeneration and variable pulse duration mechanical excitation on dorsoventral lumbar kinematic responses. SUMMARY OF BACKGROUND DATA: In vitro and in vivo biomechanical studies have examined spine kinematics during posteroanterior loading mimicking spinal manipulation therapy (SMT), but few (if any) studies have quantified SMT loading-induced spinal motion responses in the degenerated intervertebral disc. METHODS: Fifteen sheep underwent a survival surgical procedure resulting in chronic disc degeneration of the L1-L2 disc. Ten age- and weight-matched animals served as controls. Uniform pulse dorsoventral mechanical forces (80 N) were applied to the L3 spinous processes using 10-, 100-, and 200-ms duration pulses mimicking SMT. L3 displacement and L2-L1 acceleration in the control group were compared with the degenerated disc group. RESULTS: Dorsoventral displacements increased significantly (fivefold, P < 0.001) with increasing mechanical excitation pulse duration (control and degenerated disc groups). Displacements and L2-L1 acceleration transfer were significantly reduced (approximately 19% and approximately 50%, respectively) in the degenerated disc group compared with control (100- and 200-ms pulse duration protocols, P < 0.01). CONCLUSION: Dorsoventral vertebral motions are dependent on mechanical excitation pulse duration and are significantly reduced in animals with degenerated discs.
Keywords: biomechanics, degeneration, intervertebral disc, manipulation, mobilization
Rights: Copyright © 2007 Lippincott Williams & Wilkins, Inc.
RMID: 0020074252
DOI: 10.1097/BRS.0b013e318145ac39
Appears in Collections:Pathology publications

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