Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/44375
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Type: Journal article
Title: Long-chain polyunsaturated fatty acid (LCPUFA) supplementation for infants born preterm
Author: Smithers, L.
Gibson, R.
Makrides, M.
Citation: NeoReviews.org, 2007; 8(4):143-151
Publisher: American Academy of Pediatrics
Issue Date: 2007
ISSN: 1526-9906
1526-9906
Statement of
Responsibility: 
Lisa G. Smithers; Robert A. Gibson; Maria Makrides
Abstract: During gestation, the placenta actively enriches the fetal circulation with long-chain polyunsaturated fatty acids (LCPUFA), and significant quantities are concentrated in brain and retinal tissues. Preterm infants are denied the usual gestational accretion of LCPUFA, prompting the addition of these fatty acids to preterm formula. Electrophysiologic assessment of visual maturation has shown improved retinal sensitivity and visual acuity with LCPUFA formula supplementation, although the optimal dose has not been determined. Developmental assessment trials of infants fed LCPUFA-supplemented formulas have shown varied results, as have trials assessing the growth of infants fed such formulas. Comparative trials have shown no increased incidence of sepsis, necrotizing enterocolitis, or bronchopulmonary dysplasia among preterm infants fed LCPUFA-supplemented formulas. Further research is required to determine the overall balance of LCPUFA in the diets of preterm infants fed either human milk or infant formula.
Keywords: AA: arachidonic acid
BPD: bronchopulmonary dysplasia
BSID: Bayley Scales of Infant Development
CA: corrected age
DHA: docosahexaenoic acid
EPA: eicosapentaenoic acid
ERG: electroretinogram
IVH: intraventricular hemorrhage
LCPUFA: long-chain polyunsaturated fatty acids
MDI: mental development index
NEC: necrotizing enterocolitis
PDI: psychomotor development index
RCT: randomized, controlled trial
ROP: retinopathy of prematurity
VEP: visual evoked potential
Description: Copyright © 2007 by the American Academy of Pediatrics.
DOI: 10.1542/neo.8-4-e143
Published version: http://dx.doi.org/10.1542/neo.8-4-e143
Appears in Collections:Aurora harvest 6
Paediatrics publications

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