Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44479
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCai, Z.en
dc.contributor.authorBlumbergs, P.en
dc.contributor.authorFinnie, J.en
dc.contributor.authorManavis, J.en
dc.contributor.authorThompson, P.en
dc.date.issued2007en
dc.identifier.citationActa Neuropathologica, 2007; 114(2):187-194en
dc.identifier.issn0001-6322en
dc.identifier.issn1432-0533en
dc.identifier.urihttp://hdl.handle.net/2440/44479-
dc.description© Springer The original publication can be found at www.springerlink.comen
dc.description.abstractThe finding of novel fibroblastic onion bulb-like structures in peripheral nerves is reported for the first time in avian riboflavin deficiency. Day old broiler meat chickens were fed a riboflavin deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, 21 and 31, whereas control chickens were fed a conventional diet containing 5.0 mg/kg riboflavin. The fibroblastic onion bulb-like structures were found in sciatic and brachial nerves from day 11 onwards and consisted of long cytoplasmic processes of hypertrophied fibroblasts surrounding demyelinated, remyelinated and normally myelinated axons. The fibroblast cytoplasmic processes often enveloped more than one nerve fibre to produce a unique compound-like onion bulb structure. These onion bulb-like structures occurred early in the course of segmental demyelination at the same time as tomacula formation and became increasingly more prominent in the later stages of demyelination and remyelination. The molecular basis of formation of these unique structures requires further study as to the basis of the attraction of the fibroblast processes to nerve fibres associated with myelinating Schwann cells. The model may also be useful in investigating the role of endoneurial fibroblasts in endoneurial fibrosis as the early fibroblastic response in the onion bulbs is distinct from the more usual fibroblastic deposition of collagen in end-stage peripheral nerve disease.en
dc.description.statementofresponsibilityZ. Cai, P. C. Blumbergs, J. W. Finnie, J. Manavis and P. D. Thompsonen
dc.language.isoenen
dc.publisherSpringeren
dc.source.urihttp://www.springerlink.com/content/p7r408g8579v64w2/en
dc.subjectAvian riboflavin deficiency; Peripheral nerves; Demyelination; Fibroblastic onion bulbsen
dc.titleNovel fibroblastic onion bulbs in a demyelinating avian peripheral neuropathy produced by riboflavin deficiencyen
dc.typeJournal articleen
dc.identifier.rmid0020072386en
dc.identifier.doi10.1007/s00401-007-0215-8en
dc.identifier.pubid47707-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pathology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.