Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/46061
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Enhanced buprenorphine analgesia with the addition of ultra-low-dose naloxone in healthy subjects
Author: La Vincente, S.
White, J.
Somogyi, A.
Bochner, F.
Chapleo, C.
Citation: Clinical Pharmacology and Therapeutics, 2008; 83(1):144-152
Publisher: Mosby Inc
Issue Date: 2008
ISSN: 0009-9236
1532-6535
Statement of
Responsibility: 
S F La Vincente, J M White, A A Somogyi, F Bochner and C B Chapleo
Abstract: Animal studies have demonstrated that co-administration of an ultra-low-dose opioid antagonist with an opioid agonist may result in enhanced analgesia. Investigation of this effect in humans has been limited and produced inconsistent findings, with previous reports suggesting that dose ratio may be critical to analgesic potentiation. The aim of the current investigation was to determine whether buprenorphine analgesia could be enhanced with the addition of ultra-low-dose naloxone among healthy volunteers, using a range of dose ratios. Tolerance to cold pressor pain was significantly greater with the combination of buprenorphine and naloxone compared to buprenorphine alone, and this effect was dose ratio dependent. Importantly, this enhanced analgesia occurred without an increase in adverse effects; indeed at some ratios, respiratory depression was attenuated. These findings demonstrate that the addition of ultra-low-dose naloxone can enhance the analgesic effect of buprenorphine in humans without a concurrent increase in side effects.
Keywords: Humans
Buprenorphine
Naloxone
Analgesics, Opioid
Narcotic Antagonists
Pain Measurement
Treatment Outcome
Infusions, Intravenous
Double-Blind Method
Pain Threshold
Respiratory Mechanics
Dose-Response Relationship, Drug
Drug Synergism
Pressure
Time Factors
Reference Values
Adult
Female
Male
Cold Temperature
DOI: 10.1038/sj.clpt.6100262
Published version: http://dx.doi.org/10.1038/sj.clpt.6100262
Appears in Collections:Aurora harvest
Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.