Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/46400
Type: Journal article
Title: Determinants of inter-individual cholesterol level variation in an unbiased young male sample
Author: Ruhli, F.
Henneberg, M.
Schaer, D.
Imhof, A.
Schleiffenbaum, B.
Woitek, U.
Citation: Swiss Medical Weekly, 2008; 138(19-20):286-291
Publisher: E M H Swiss Medical Publishers Ltd
Issue Date: 2008
ISSN: 1424-7860
1424-3997
Statement of
Responsibility: 
Rühli FJ, Henneberg M, Schär DJ, Imhof A, Schleiffenbaum B, Woitek U.
Abstract: Question under study: Affected by individual life style, the total cholesterol serum level is a major morbidity and mortality risk factor for atherosclerotic cardiovascular disease (CVD). We present total cholesterol values and their possible aetiological factors of young Swiss conscripts. Particularly, we study varying impact of these factors depending on different levels of individual cholesterol. Methods: Male conscripts (n = 19,272) of the 2005 census of the conscripts have been examined, reflecting ca. 59% of a total Swiss male birth cohort. Quantile regression allows us to analyse responses of arbitrary quantiles with respect to variables of interest. Results: Eleven percent of all conscripts show clinically important increased total cholesterol levels. There is a major association of high individual cholesterol level with French regional language. The largest socio-economic subsample – agricultural and construction workers – show significantly higher individual cholesterol levels than employees in the industry sector and students, respectively. Conclusions: We were able to find that culture, as indicated by the mother tongue, and socioeconomic status as indicated by profession/vocation, influence individual total cholesterol levels while climate as indicated by altitude does not have an influence on cholesterol levels. Such a broad screening programme offers a unique opportunity to target persons at high-risk for CVD morbidity and mortality already early in life.
Keywords: Humans; Hypercholesterolemia; Cholesterol; Risk Factors; Cohort Studies; Life Style; Reference Values; Social Environment; Socioeconomic Factors; Multilingualism; Adult; Military Personnel; Switzerland; Male; Atherosclerosis
Description: Copyright © 2008 EMH Swiss Medical Publishers Ltd.
RMID: 0020080749
Published version: http://www.smw.ch/docs/archive200x/2008/19/smw-11971.html
Appears in Collections:Anatomical Sciences publications

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