Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/46659
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Type: Journal article
Title: Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection
Author: Bayston, R.
Nuradeen, B.
Ashraf, W.
Freeman, B.
Citation: Journal of Antimicrobial Chemotherapy, 2007; 60(6):1298-1301
Publisher: Oxford Univ Press
Issue Date: 2007
ISSN: 0305-7453
1460-2091
Statement of
Responsibility: 
Roger Bayston, Bryar Nuradeen, Waheed Ashraf and Brian J. C. Freeman
Abstract: Objectives: Propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated. We therefore investigated the effect of two different courses of three antibiotics (penicillin, rifampicin and linezolid) on mature P. acnes biofilms in vitro. Outcomes were eradication or regrowth after withdrawal of antibiotics, simulating successful treatment and relapse. Methods: P. acnes biofilms were grown on titanium discs for 6 days until mature, then exposed to the antibiotics for either 7 or 14 days before sonication and culture. Further, discs were similarly exposed, but after each course, they were reincubated for a further 9 days to check for regrowth. Results: Penicillin, linezolid and linezolid plus rifampicin eradicated P. acnes biofilms after 14 days, but only penicillin had this effect after 7 days. ‘Relapse’ was prevented only by 14 day courses of penicillin or linezolid plus rifampicin, but not by linezolid alone. Conclusions: For P. acnes spinal instrumentation infections, either penicillin or linezolid plus rifampicin might be equally effective. For shunt infections, as penicillin does not give therapeutic cerebrospinal fluid concentrations, rifampicin plus linezolid might be the treatment of choice. Linezolid alone appears not to be as effective as penicillin against P. acnes biofilms.
Keywords: orthopaedic implants; spinal instrumentation; hydrocephalus shunts; P. acne
Description: © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
RMID: 0020081143
DOI: 10.1093/jac/dkm408
Published version: http://jac.oxfordjournals.org/cgi/content/abstract/60/6/1298
Appears in Collections:Orthopaedics and Trauma publications

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