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https://hdl.handle.net/2440/46935
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Type: | Journal article |
Title: | Gene expression in sheep skin and wool (hair) |
Author: | Adelson, D. Cam, G. DeSilva, U. Franklin, I. |
Citation: | Genomics, 2004; 83(1):95-105 |
Publisher: | Academic Press Inc Elsevier Science |
Issue Date: | 2004 |
ISSN: | 0888-7543 1089-8646 |
Abstract: | We sequenced 2939 ESTs from fetal and adult sheep skin. Stages of gestation were picked to coincide with the major events in skin appendage (wool follicle) formation. Clustering analysis generated a nonredundant set of ESTs 2435 strong (83% nonredundant). Approximately 24% of these gave no hit to NCBI build 29 of the human genome, while 35% were tentatively classified by putative function based on BLASTX hits with a p(N) of <10⁻⁴. In addition to bioinformatics analysis of our ESTs and gene mapping, we have generated a large EST spatial expression data set using in situ hybridization. One thousand one hundred forty-two ESTs have been used for in situ localization; about 31% are from adult sheep skin, 39% from late gestation fetal sheep skin, and 30% from midgestation fetal sheep skin. These probes have been used in over 3000 hybridization experiments. In this report, we summarize the results of in situs on adult sheep skin. |
Keywords: | wool follicle |
DOI: | 10.1016/S0888-7543(03)00210-6 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/622838/description#description |
Published version: | http://dx.doi.org/10.1016/s0888-7543(03)00210-6 |
Appears in Collections: | Aurora harvest 6 Environment Institute publications Molecular and Biomedical Science publications |
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