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Type: Journal article
Title: Backbone cleavages of [M - H]- anions derived from caerin 1 peptides and some synthetic modifications. Molecular recognition initiating internal cyclisation of Glu23
Author: Brinkworth, C.
Bowie, J.
Citation: Rapid Communications in Mass Spectrometry, 2002; 16(14):1339-1351
Publisher: John Wiley & Sons Ltd
Issue Date: 2002
ISSN: 0951-4198
Statement of
Craig S. Brinkworth, John H. Bowie
Abstract: The collision induced spectra of [M - H](-) anions from of caerin 1 peptides and some synthetic modifications show the usual alpha, beta and beta' backbone cleavages together with Ser (epsilon,gamma) and Glu (gamma) cleavages which break the peptide backbone in the vicinity of those residues. All of these cleavages require the peptide backbone to be flexible. There is also a backbone cleavage of a type not observed before. This cleavage involves nucleophilic attack of the carboxylate anion of the Glu23 side chain at the backbone CH of Ile 21. We propose that this cleavage requires the caerin peptide to be in an alpha helical conformation (the 3D structure that this peptide adopts in solution) in order that the interacting groups are held in close proximity.
Keywords: Animals
Glutamic Acid
Antimicrobial Cationic Peptides
Peptide Fragments
Amphibian Proteins
Spectrometry, Mass, Fast Atom Bombardment
Molecular Structure
Amino Acid Sequence
Protein Structure, Secondary
Models, Molecular
Molecular Sequence Data
Description: The definitive version may be found at
Provenance: Published Online: 12 Jun 2002
DOI: 10.1002/rcm.719
Published version:
Appears in Collections:Aurora harvest 2
Chemistry publications

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