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https://hdl.handle.net/2440/4838
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Type: | Journal article |
Title: | Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate |
Author: | Boontheung, P. Brinkworth, C. Bowie, J. Baudinette, R. |
Citation: | Rapid Communications in Mass Spectrometry, 2002; 16(4):287-292 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2002 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Pinmanee Boontheung, Craig S. Brinkworth, John H. Bowie, Russell V. Baudinette |
Abstract: | The positive ion electrospray mass spectra of [M+H](+) and the negative ion electrospray mass spectra of [M-H](-) ions of selected pyroglutamate containing peptides both provide sequencing data. The negative ion spectra show the normal alpha and beta backbone cleavages in addition to delta and gamma backbone cleavages initiated by the side chains of Glu and Phe residues. For example, the [M-H](-) ion of pGlu Pro Gln Val Phe Val-NH(2) shows delta and gamma peaks at m/z 224 (delta, Gln3), 244 (gamma, Phe4), 451 (delta, Phe4), 471 (gamma, Gln3). Some of the negative ion spectra show unusual grandaughter peaks that originate by alpha and beta, or delta and gamma backbone cleavages of a beta(1) cleavage ion. |
Keywords: | Animals Macropodidae Pyrrolidonecarboxylic Acid Peptides Spectrometry, Mass, Electrospray Ionization Female |
Description: | The definitive version may be found at www.wiley.com |
Provenance: | Published Online: 15 Jan 2002 |
DOI: | 10.1002/rcm.576 |
Published version: | http://www3.interscience.wiley.com/journal/89014695/abstract |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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