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Type: Journal article
Title: Staining of amyloid precursor protein to study axonal damage in mild head injury
Author: Blumbergs, P.
Scott, G.
Manavis, J.
Wainwright, H.
Simpson, D.
McLean, J.
Citation: The Lancet, 1994; 344(8929):1055-1056
Publisher: LANCET LTD
Issue Date: 1994
ISSN: 0140-6736
Organisation: Centre for Automotive Safety Research (CASR)
Statement of
P.C. Blumbergs, G. Scott, J. Manavis , H. Wainwright, D.A. Simpson & A.J. McLean
Abstract: The most common definition of cerebral concussion is that of a transient loss of neurological function without macroscopic or microscopic abnormality in the brain. However, some patients have persistent symptoms and subtle neuropsychological deficits, particularly affecting memory. We have studied five patients aged 59-89 years who sustained mild concussive head injury and died of other causes (2-99 days post-injury). Immunostaining with an antibody to amyloid precursor protein, a marker of fast axonal transport, showed multifocal axonal injury in all five. All had axonal damage in the fornices, which are important in memory function.
Keywords: Axons; Humans; Brain Concussion; Craniocerebral Trauma; Amyloid beta-Protein Precursor; Immunohistochemistry; Axonal Transport; Brain Chemistry; Aged; Aged, 80 and over; Middle Aged; Biomarkers
Description: (c) 1994 the Lancet
RMID: 0030001406
DOI: 10.1016/S0140-6736(94)91712-4
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Appears in Collections:Centre for Automotive Safety Research publications

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