Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/50577
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Type: Journal article
Title: Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial
Author: Mohd Zain, M.
Jamaluddin, R.
Ibrahim, A.
Norman, R.
Citation: Fertility and Sterility, 2009; 912(2):514-521
Publisher: Elsevier Science Inc
Issue Date: 2009
ISSN: 0015-0282
1556-5653
Statement of
Responsibility: 
Murizah Mohd Zain, Ridzuan Jamaluddin, Adibah Ibrahim and Robert J. Norman
Abstract: Objective To determine the first-line medication to be used in anovulatory patients with polycystic ovary syndrome (PCOS) for ovulation induction and pregnancy achievement. Design Randomized controlled trial. Setting Infertility unit of a public hospital. Patient(s) One hundred fifteen newly diagnosed patients with PCOS based on ESHRE/ASRM criteria. Intervention(s) These patients were assigned to three groups: group 1 (38 patients) received 500 mg of metformin three times a day; group 2 (39 patients) received clomiphene citrate (CC) at an incremental dose; group 3 (38 patients) received both medications. Main Outcome Measure(s) Rates of ovulation, pregnancy (PR), and live birth. Result(s) The ovulation rate was 23.7% in the metformin group, 59% in the CC group, and 68.4% in the combination treatment group. This was translated into a similar PR and live birth rate, which were higher in the CC and combination groups compared to the metformin group (PR: 7.9%, 15.4%, and 21.1%; live birth rate: 7.9%, 15.4%, and 18.4% in metformin, CC, and combination treatment groups, respectively), although statistically the differences were not significant. There were no multiple pregnancies and the rate of spontaneous first trimester loss was similar to the general population. Conclusion(s) Clomiphene citrate should be the first-line treatment for ovulation induction in anovulatory patients with PCOS.
Keywords: Humans
Polycystic Ovary Syndrome
Anovulation
Infertility, Female
Metformin
Clomiphene
Fertility Agents, Female
Treatment Outcome
Drug Therapy, Combination
Ovulation Induction
Pregnancy Rate
Prospective Studies
Ovulation
Pregnancy
Adult
Female
Live Birth
Asian People
Description: Copyright © 2009 American Society for Reproductive Medicine
DOI: 10.1016/j.fertnstert.2007.12.002
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/600420/description#description
Published version: http://dx.doi.org/10.1016/j.fertnstert.2007.12.002
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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