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https://hdl.handle.net/2440/50635
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dc.contributor.author | Thompson, S. | - |
dc.contributor.author | Cai, W. | - |
dc.contributor.author | Jamieson, G. | - |
dc.contributor.author | Zhang, A. | - |
dc.contributor.author | Myers, J. | - |
dc.contributor.author | Parr, Z. | - |
dc.contributor.author | Watson, D. | - |
dc.contributor.author | Persson, J. | - |
dc.contributor.author | Holtmann, G. | - |
dc.contributor.author | Devitt, P. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Gastrointestinal Surgery, 2009; 13(1):54-60 | - |
dc.identifier.issn | 1091-255X | - |
dc.identifier.issn | 1873-4626 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50635 | - |
dc.description | © 2008 The Society for Surgery of the Alimentary Tract | - |
dc.description.abstract | Introduction A small cohort of patients present after antireflux surgery complaining of recurrent heartburn. Over two thirds of these patients will have a negative 24-h pH study. The aim of our study is to determine whether these patients have an associated functional disorder or abnormal cytokine activity and to examine the reproducibility of pH testing. Methods A prospective analysis was carried out on a cohort of patients who had undergone a fundoplication and postoperative pH testing for recurrent heartburn: group A—patients with recurrent heartburn and a negative 24-h pH study and group B (control group)—patients with recurrent heartburn and a positive pH study. Questionnaires, a blood sample, and repeat pH testing were completed. Results Sixty-nine patients were identified. Group A’s depression score (8.6 ± 4.1) was significantly higher than group B’s (5.9 ± 4.2; P = 0.03). Cytokine levels were similar in both groups. Forty-seven of 49 (96%) patients who underwent repeat pH testing had a negative study. Symptom-reflux correlation was highly significant (P < 0.001). Conclusion Some patients with recurrent heartburn and a negative pH study have associated functional or psychiatric comorbidities such as depression. Reproducibility of 24-h pH testing in these patients is excellent. | - |
dc.description.statementofresponsibility | Sarah K. Thompson, Wang Cai, Glyn G. Jamieson, Alison Y. Zhang, Jennifer C. Myers, Zoe E. Parr, David I. Watson, Jenny Persson, Gerald Holtmann and Peter G. Devitt | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Svience Inc | - |
dc.source.uri | http://dx.doi.org/10.1007/s11605-008-0653-1 | - |
dc.subject | Humans | - |
dc.subject | Gastroesophageal Reflux | - |
dc.subject | Recurrence | - |
dc.subject | Heartburn | - |
dc.subject | Laparoscopy | - |
dc.subject | Prognosis | - |
dc.subject | Fundoplication | - |
dc.subject | Postoperative Period | - |
dc.subject | Risk Factors | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Prospective Studies | - |
dc.subject | Hydrogen-Ion Concentration | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Esophageal pH Monitoring | - |
dc.title | Recurrent Symptoms after Fundoplication with a Negative pH Study--Recurrent Reflux or Functional Heartburn? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s11605-008-0653-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Myers, J. [0000-0003-2157-7098] | - |
Appears in Collections: | Aurora harvest 5 Surgery publications |
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